SynthesisMedicine2018
The prognostic value of HOTAIR for predicting long-term prognosis of patients with gastrointestinal cancers.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- HOTAIR as a diagnostic and prognostic biomarker of gastrointestinal cancers: an updated meta-analysis and bioinformatics analysis based on TCGA data.Bioscience reports · 2023Pooled it
- Effect of tumor exosome-derived Lnc RNA HOTAIR on the growth and metastasis of gastric cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Article
- Analysis of a Four-Component Competing Endogenous RNA Network Reveals Potential Biomarkers in Gastric Cancer: An Integrated Systems Biology and Experimental Investigation.Advanced biomedical research · 2023Article
- Non-coding RNAs and gastrointestinal cancers prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies.Frontiers in oncology · 2023Article
- LncRNA HOTAIR promotes breast cancer progression through regulating the miR-129-5p/FZD7 axis.Cancer biomarkers : section A of Disease markers · 2021Article
- Roles and Mechanisms of the Long Noncoding RNAs in Cervical Cancer.International journal of molecular sciences · 2020Review
- Prognostic Value of LncRNA HOTAIR in Colorectal Cancer: A Meta-analysis.Open medicine (Warsaw, Poland) · 2020Article
- Article
- [Preliminary Study on the Biological Markers for I-IIb Stage Non-small Cell Lung Cancer Based on a Serum-peptidomics].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2019Article
- BC200 RNA: An Emerging Therapeutic Target and Diagnostic Marker for Human Cancer.Molecules and cells · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased expression of HOX transcription antisense RNA (HOTAIR) has been reported to be associated with unfavorable prognosis in cancer patients. Several studies have evaluated the significance of HOTAIR in the development and progression of gastrointestinal cancers (GICs).
methodsSystematic literature retrieval was performed by searching keywords in several electronic databases, including PubMed, Embase, Web of Science, CNKI, Springer, Google Scholar, and GEO. Relevant articles on association between HOTAIR expression levels and prognosis in patients with GIC were collected and screened with eligible criteria. The RevMan 5.2 software and Stata SE12.0 software was applied.
resultsA total of 1297 patients from 15 eligible articles were included in this meta-analysis. The results revealed that increased expression of HOTAIR was significantly associated with shorter overall survival (OS) in GIC patients [hazard ratio (HR) = 1.93, 95% CI: 1.64-2.26], as well as poorer disease-free survival (DFS) (HR = 2.79; 95% CI: 1.38-5.63). Additionally, the pooled odds ratio (OR) indicated that increased HOTAIR was associated with clinicopathological parameters, including lymph node metastasis (OR = 2.48, 95% CI: 1.71-3.61), distant metastasis (OR = 4.34, 95% CI: 2.12-8.91), poor tumor differentiation (OR = 2.90, 95% CI: 1.45-5.80), lymphovascular invasion (OR = 2.86, 95% CI: 1.83-4.46), high depth of tumor invasion (OR = 2.07, 95% CI: 1.36-3.16), and poor clinical stage (OR = 2.72, 95% CI: 1.70-4.35). In survival analysis through the Kaplan-Meier plotter database, enhanced level of HOTAIR was associated with better OS and DFS in gastric cancer patients.
conclusionsHigh expression level of HOTAIR was related to poor clinical outcome of GIC patients. The HOTAIR could be applied as potential biomarker for assessing the prognosis. Further well-designed studies should be performed to verify the clinical applications of HOTAIR in GIC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.