Evidence map›Paper›PMID 29954744›Full record

Observational studyJournal of the American Heart Association2018

Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study.

Basmah Safdar, Erica S Spatz, Rachel P Dreyer, John F Beltrame, Judith H Lichtman, John A Spertus, Harmony R Reynolds, Mary Geda, Héctor Bueno, James D Dziura and 2 more

3 registry-linked trialsOpen access · goldAbstract readComparative StudyMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 190 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 5 pooled it
27.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05122780 phase4unknown statusstarted 2021, after this paper: background citation

PROgnostic Value of Precision Medicine in Patients With Myocardial Infarction and Non-obStructive Coronary artEries: the PROMISE Trial.

Ran2021Enrolled120Registered outcomes17Posted comparisons0ConditionsMyocardial Infarction With Non-Obstructive Coronary ArteriesArmsACEi/ARB, Acetylcholine provocative test, Anticoagulant, Antiplatelet Drug, Beta Blocker
PMID 30772224PMID 32628045PMID 31709984PMID 31270616PMID 30913893PMID 25587100PMID 30343094PMID 30266608PMID 29228159PMID 28624816PMID 28476516PMID 28239487other papers from this trial
Open the trial in the graph
NCT00597922 completednot on this map

Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction (AMI) Patients (VIRGO)

TypeobservationalSponsorYale UniversityRan2007 to 2013Enrolled2,985ConditionsAcute Myocardial Infarction
NCT05326828 recruitingnot on this mapstarted 2022, after this paper: background citation

Implantable Cardiac Monitor to Detect Atrial Fibrillation in Patients With MINOCA

TypeobservationalSponsorInsel Gruppe AG, University Hospital BernRan2022 to 2031Enrolled60ConditionsMINOCA, Atrial FibrillationArmsCONFIRM Rx implantable cardiac rhythm monitor (Abbott), Systematic etiologic work-up for underlying causes of MINOCA
3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 5 syntheses or guidelines pooled it, 426 citations in OpenAlex.

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130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Basmah SafdarDepartment of Emergency Medicine, Yale University, New Haven, CT basmah.safdar@yale.edu.
Erica S SpatzSection of Cardiovascular Medicine, Department of Medicine, Yale University, New Haven, CT.
Rachel P DreyerDepartment of Emergency Medicine, Yale University, New Haven, CT.
John F BeltrameQueen Elizabeth Hospital, University of Adelaide, Australia.
Judith H LichtmanYale School of Public Health, New Haven, CT.
John A SpertusUniversity of Missouri Kansas City, Kansas City, MO.
Harmony R ReynoldsCardiovascular Clinical Research Center, NYU School of Medicine, New York, NY.
Mary GedaCenter for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT.
Héctor BuenoCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
James D DziuraDepartment of Emergency Medicine, Yale University, New Haven, CT.
Harlan M KrumholzSection of Cardiovascular Medicine, Department of Medicine, Yale University, New Haven, CT.
Gail D'OnofrioDepartment of Emergency Medicine, Yale University, New Haven, CT.
Yale University · USYale New Haven Hospital · USHospital Universitario 12 De Octubre · ESQueen Elizabeth Hospital · AUSaint Luke's Hospital · US

Funding

NHLBI NIH HHS R01 HL081153
6 · The paper itself

Abstract

backgroundWe compared the clinical characteristics and outcomes of young patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) versus obstructive disease (myocardial infarction due to coronary artery disease [MI-CAD]) and among patients with MINOCA by sex and subtype. METHODS AND

resultsBetween 2008 and 2012, VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients) prospectively enrolled acute myocardial infarction patients aged 18 to 55 years in 103 hospitals at a 2:1 ratio of women to men. Using an angiographically driven taxonomy, we defined patients as having MI-CAD if there was revascularization or plaque ≥50% and as having MINOCA if there was <50% obstruction or a nonplaque mechanism. Patients who did not have an angiogram or who received thrombolytics before an angiogram were excluded. Outcomes included 1- and 12-month mortality and functional (Seattle Angina Questionnaire [SAQ]) and psychosocial status. Of 2690 patients undergoing angiography, 2374 (88.4%) had MI-CAD, 299 (11.1%) had MINOCA, and 17 (0.6%) remained unclassified. Women had 5 times higher odds of having MINOCA than men (14.9% versus 3.5%; odds ratio: 4.84; 95% confidence interval, 3.29-7.13). MINOCA patients were more likely to be without traditional cardiac risk factors (8.7% versus 1.3%;

conclusionsYoung patients with MINOCA were more likely women, had a heterogeneous mechanistic profile, and had clinical outcomes that were comparable to those of MI-CAD patients. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00597922.

Indexed as

AdolescentAdultAge of OnsetCoronary AngiographyCoronary Artery DiseaseFemaleHumansMaleMiddle AgedNon-ST Elevated Myocardial InfarctionProspective StudiesRisk AssessmentRisk FactorsSex FactorsST Elevation Myocardial InfarctionTime Factorsacute myocardial infarctionmyocardial infarction with nonobstructive coronary arteriesnonobstructiveprognosissexwomen

Identifiers

PMID29954744
PMCPMC6064896
OpenAlexW2810046517

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.