ArticleDrug safety2018
Role of Serotonin Transporter in Antidepressant-Induced Diabetes Mellitus: A Pharmacoepidemiological-Pharmacodynamic Study in VigiBase
Article in Drug safety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Short-Term Risk of Type 2 Diabetes in Patients Using Various Antidepressants Compared with Patients Using Fluoxetine.Psychiatry and clinical psychopharmacology · 2024Article
- Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression.CNS neuroscience & therapeutics · 2024Review
- A study of the regional differences in propacetamol-related adverse events using VigiBase data of the World Health Organization.Scientific reports · 2022Article
- Identifying Antidepressants Less Likely to Cause Hyponatremia: Triangulation of Retrospective Cohort, Disproportionality, and Pharmacodynamic Studies.Clinical pharmacology and therapeutics · 2022Article
- Pathway-based protein-protein association network to explore mechanism of α-glucosidase inhibitors from Scutellaria baicalensis Georgi against type 2 diabetes.IET systems biology · 2021Article
- Association of first-line antidepressants and incident adverse metabolic effects.Canadian family physician Medecin de famille canadien · 2020Review
- Role of serotonin and norepinephrine transporters in antidepressant-induced arterial hypertension: a pharmacoepidemiological-pharmacodynamic study.European journal of clinical pharmacology · 2020Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between antidepressant exposure and type 2 diabetes mellitus is still debated. Moreover, the pharmacological mechanisms remain unknown.
objectiveThe objective of this study was to investigate this putative relationship with the role of antidepressant pharmacological targets using the 'pharmacoepidemiological-pharmacodynamic' method.
methodsFirst, we performed case/non-case analyses in VigiBase
resultsA significant type 2 diabetes signal was found for antidepressants in general, three classes of antidepressants (tricyclic antidepressants, serotonin reuptake inhibitors and "other" antidepressants) and 15 individual antidepressants in particular. Among the antidepressants, three serotonin reuptake inhibitors [escitalopram (adjusted reporting odds ratio 1.15 [1.07-1.25]), paroxetine (1.15 [1.07-1.23]), sertraline (1.23 [1.17-1.31])] and three "other" antidepressants [duloxetine (1.15 [1.07-1.23]), trazodone (1.20 [1.09-1.32]), venlafaxine (1.15 [1.08-1.23])] were the antidepressants most frequently reported with type 2 diabetes. We found a significant correlation between the type 2 diabetes signal and serotonin transporter affinity (slope = 0.14 [0.06-0.23], p = 0.003, R
conclusionThe present study suggests a potential role for serotonin transporter in antidepressant-induced type 2 diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.