ArticleJournal of the American Heart Association2018
Lack of a Tricuspid Regurgitation Doppler Signal and Pulmonary Hypertension by Invasive Measurement.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Doppler trans-thoracic echocardiography for detection of pulmonary hypertension in adults.The Cochrane database of systematic reviews · 2022Pooled it
- Prevalence and Mortality of Pulmonary Hypertension in ESRD: A Systematic Review and Meta-analysis.Lung · 2020Pooled it
- Article
- TAPSE/PAi, a practical echocardiographic functional-structural index, better reflects functional severity than TAPSE/sPAP in pulmonary hypertension.BMC cardiovascular disorders · 2026Article
- Incident Pulmonary Hypertension and Its Risk Factors in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Left atrial reservoir strain and the left atrioventricular coupling index in association with left ventricular diastolic dysfunction in non-dialysis chronic kidney disease with preserved ejection fraction: a cross-sectional study.BMC cardiovascular disorders · 2026Article
- 4D flow MRI-based grading of left ventricular diastolic dysfunction: a validation study against echocardiography.European radiology · 2025Article
- The value of echocardiographic left ventricular rotational body volume analysis in the assessment of patients with pulmonary hypertension.Quantitative imaging in medicine and surgery · 2025Article
- Clinical research on echocardiographic screening for pulmonary hypertension: TRV >2.8 m/s and mPAP >20 mmHg.Quantitative imaging in medicine and surgery · 2025Article
- Clinical validation of a machine-learned, point-of-care system to IDENTIFY pulmonary hypertension.ERJ open research · 2025Article
- New Echocardiographic Algorithm for Estimating Right Atrial Pressure in Severe Tricuspid Regurgitation: Insights From Simultaneous Cardiac Catheterization.Journal of the American Heart Association · 2025Observational
- Prognostic Applications of Current Clinical Scores in Heart Failure with Preserved Ejection Fraction: A Prospective Cohort Study.Arquivos brasileiros de cardiologia · 2025Article
- Incidence of Pulmonary Hypertension in the Echocardiography Referral Population.Annals of the American Thoracic Society · 2025Article
- High pulmonary hypertension risk by echocardiogram shortens survival in polycythemia vera.Blood advances · 2025Article
- An ensemble learning model for detection of pulmonary hypertension using electrocardiogram, chest X-ray, and brain natriuretic peptide.European heart journal. Digital health · 2025Article
- A multi-biomarker approach to risk stratification and detection of early cardiac disease in systemic sclerosis.PloS one · 2025Observational
- Tricuspid valve flow measurement using a deep learning framework for automated valve-tracking 2D phase contrast.Magnetic resonance in medicine · 2024Article
- Two prospective, multicenter studies for the identification of biomarker signatures for early detection of pulmonary hypertension (PH): The CIPHER and CIPHER-MRI studies.Pulmonary circulation · 2024Article
- A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function.European journal of heart failure · 2024Article
- A better method to evaluate the reliability of echocardiography for assessment of pulmonary hypertension: comparison of tricuspid regurgitant spectrum quality grading and tricuspid valve regurgitation degree.Journal of thoracic disease · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTransthoracic echocardiography (TTE) is used to estimate pulmonary artery systolic pressure, but an adequate tricuspid regurgitation velocity (TRV) needed to calculate pulmonary artery systolic pressure is not always present. It is unknown whether the absence of a measurable TRV signifies normal pulmonary artery pressure. METHODS AND
resultsWe extracted hemodynamic, TTE, and clinical data from Vanderbilt's deidentified electronic medical record in all patients referred for right heart catheterization between 1998 and 2014. Pulmonary hypertension (PH) was defined as mean pulmonary artery pressure ≥25 mm Hg. We examined the prevalence and clinical correlates of PH in patients without a reported TRV. We identified 1262 patients with a TTE within 2 days of right heart catheterization. In total, 803/1262 (64%) had a reported TRV, whereas 459 (36%) had no reported TRV. Invasively confirmed PH was present in 47% of patients without a reported TRV versus 68% in those with a reported TRV (
conclusionsPH is present in almost half of patients without a measurable TRV who are referred for both TTE and right heart catheterization. Clinical and echocardiographic features of left heart disease are associated with invasively confirmed PH in subjects without a reported TRV. Clinicians should use caution when making assumptions about PH status in the absence of a measurable TRV on TTE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.