Evidence map›Paper›PMID 29970616›Full record

ArticleThe Journal of biological chemistry2018

Region-specific proteolysis differentially modulates type 2 and type 3 inositol 1,4,5-trisphosphate receptor activity in models of acute pancreatitis.

Liwei Wang, Larry E Wagner, Kamil J Alzayady, David I Yule

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Differential regulation of ion channels function by proteolysis.Biochimica et biophysica acta. Molecular cell research · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Liwei WangFrom the Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642.
Larry E WagnerFrom the Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642.
Kamil J AlzayadyFrom the Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642.
David I YuleFrom the Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642 david_yule@urmc.rochester.edu.ORCID 0000-0002-6743-0668
University of Rochester · US

Funding

[Ca2+]i and Secretory Dynamics in Parotid Acinar CellsR01DE014756 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2002 to 2026
$9.9M
An experimental/computational approach for understanding salivary fluid secretionR01DE019245 · NIDCR · UNIVERSITY OF ROCHESTER · PI David I Yule · 2008 to 2026
$9.7M
NIDCR NIH HHS R01 DE014756NIDCR NIH HHS R01 DE019245
6 · The paper itself

Abstract

Fine-tuning of the activity of inositol 1,4,5-trisphosphate receptors (IP

Indexed as

Calcium SignalingDisease Models, AnimalAcute DiseaseAnimalsInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsIon Channel GatingMaleMiceMice, Inbred C57BLPancreatitisProteolysisRatsRats, WistarInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate Receptorscalcium intracellular releaseinositol 1,4,5-trisphosphate (IP3)inositol trisphosphate receptor (IP3R)pancreasproteaseproteolysis

Identifiers

PMID29970616
PMCPMC6109931
OpenAlexW2810712078

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.