Trial reportDiabetes, obesity & metabolism2018
The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans.
Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Diabetes, obesity & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 93 citations in OpenAlex.
- The Metabolomic Effects of Tripeptide Gut Hormone Infusion Compared to Roux-en-Y Gastric Bypass and Caloric Restriction.The Journal of clinical endocrinology and metabolism · 2022Trial
- The Effects of Kisspeptin on Brain Response to Food Images and Psychometric Parameters of Appetite in Healthy Men.The Journal of clinical endocrinology and metabolism · 2021Trial
- Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects.Experimental biology and medicine (Maywood, N.J.) · 2021Trial
- Acute Effects of Glucagon on Reproductive Hormone Secretion in Healthy Men.The Journal of clinical endocrinology and metabolism · 2020Trial
- Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome.Human reproduction (Oxford, England) · 2019Trial
- The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans.Diabetes, obesity & metabolism · 2018Trial
- Enzymatic Stability and Comparative Effects of Kisspeptin-14, Kisspeptin-13 and Kisspeptin-10 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation.Metabolites · 2026Article
- Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats.Acta physiologica (Oxford, England) · 2026Article
- Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice.Biomolecules · 2025Article
- Melanocortin-responsive Kiss1 neurons of the arcuate nucleus drive energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus.bioRxiv : the preprint server for biology · 2025Article
- Kisspeptin and neurokinin B: roles in reproductive health.Physiological reviews · 2025Review
- Kisspeptin Alleviates Human Hepatic Fibrogenesis by Inhibiting TGFβ Signaling in Hepatic Stellate Cells.Cells · 2024Article
- Adipose tissue-derived metabolite risk scores and risk for type 2 diabetes in South Asians.International journal of obesity (2005) · 2024Article
- The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome.Reviews in endocrine & metabolic disorders · 2024Review
- Kisspeptin a potential therapeutic target in treatment of both metabolic and reproductive dysfunction.Journal of diabetes · 2024Review
- Kisspeptin upregulates β-cell serotonin production during pregnancy.The Journal of endocrinology · 2024Article
- Article
- The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B.Endocrine reviews · 2024Review
- Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity.Scientific reports · 2023Article
- The effects of kisspeptin on food intake in women with overweight or obesity.Diabetes, obesity & metabolism · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 9 institutions in 3 countries.
Chioma Izzi-EngbeayaSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.ORCID 0000-0001-7599-0166
Alexander N ComninosSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Sophie A ClarkeSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Anne JomardSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Lisa YangSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Sophie JonesSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Ali AbbaraSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Shakunthala NarayanaswamySection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Pei Chia EngSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Deborah PapadopoulouSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Julia K PragueSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Paul BechSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Ian F GodslandSection of Metabolic Medicine, Department of Medicine, Imperial College London, St Mary's Hospital, London, UK.
Paul BassettStatsconsultancy Ltd, Amersham, UK.
Caroline SandsThe MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
Stephane CamuzeauxThe MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
Maria Gomez-RomeroThe MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
Jake T M PearceThe MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
Matthew R LewisThe MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
Elaine HolmesThe MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
Jeremy K NicholsonThe MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
Tricia TanSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Risheka RatnasabapathySection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Ming HuSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Gaelle CarratSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Lorenzo PiemontiDiabetes Research Institute (SR-DRI), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Marco BuglianiDepartment of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa, Italy.ORCID 0000-0002-1744-1561
Piero MarchettiDepartment of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa, Italy.
Paul R JohnsonNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Stephen J HughesNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
A M James ShapiroClinical Islet Laboratory and Clinical Islet Transplant Program, University of Alberta, Edmonton, Canada.
Guy A RutterSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
Waljit S DhilloSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.ORCID 0000-0001-5950-4316
Imperial College London · GBNIHR Imperial Biomedical Research Centre · GBHammersmith Hospital · GBChurchill Hospital · GBUniversity of Pisa · ITImperial College Healthcare NHS Trust · GBSt Mary's Hospital · GBUniversity of Alberta · CAVita-Salute San Raffaele University · IT
Funding
Biotechnology and Biological Sciences Research CouncilDepartment of Health RP‐2014‐05‐001Medical Research Council MR/J0003042/1Medical Research Council MR/K001981/1Medical Research Council MR/L020149/1Medical Research Council MR/M004171/1Medical Research Council MR/N00275X/1Medical Research Council MR/N020472/1Medical Research Council MR/R000484/1Wellcome Trust WT098424AIA
Abstract
aimsTo investigate the effect of kisspeptin on glucose-stimulated insulin secretion and appetite in humans. MATERIALS AND
methodsIn 15 healthy men (age: 25.2 ± 1.1 years; BMI: 22.3 ± 0.5 kg m
resultsKisspeptin administration to healthy men enhanced insulin secretion following an intravenous glucose load, and modulated serum metabolites. In keeping with this, kisspeptin increased glucose-stimulated insulin secretion from human islets and a human pancreatic cell line in vitro. In addition, kisspeptin administration did not alter gut hormones, appetite or food intake in healthy men.
conclusionsCollectively, these data demonstrate for the first time a beneficial role for kisspeptin in insulin secretion in humans in vivo. This has important implications for our understanding of the links between reproduction and metabolism in humans, as well as for the ongoing translational development of kisspeptin-based therapies for reproductive and potentially metabolic conditions.
Indexed as
AdolescentAdultAppetiteCell LineGlucoseHealthy VolunteersHumansInsulinInsulin-Secreting CellsInsulin SecretionKisspeptinsMaleYoung AdultGlucoseInsulinKisspeptinsappetite controlbeta cell functionglucose metabolismincretinsinsulin secretionislets
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.