Evidence map›Paper›PMID 29992026›Full record

Trial reportPharmacology research & perspectives2018

Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of

Pernilla Haage, Robert Kronstrand, Martin Josefsson, Simona Calistri, Ron H N van Schaik, Henrik Green, Fredrik C Kugelberg

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pharmacology research & perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Metabolic ratios and SNPs implicated in tramadol-related deaths.International journal of legal medicine · 2023
    Article
  5. CYP2D6 pharmacogenetics and phenoconversion in personalized medicine.Expert opinion on drug metabolism & toxicology · 2022
    Review
  6. The Role of Pharmacogenomics in Postoperative Pain Management.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  7. Different Pharmacokinetics of Tramadol,Frontiers in pharmacology · 2021
    Article
  8. Gene polymorphism impact on opioid analgesic usage.Journal of advanced pharmaceutical technology & research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Pernilla HaageDepartment of Forensic Genetics and Forensic Toxicology National Board of Forensic Medicine Linköping Sweden.ORCID 0000-0003-0650-8633
Robert KronstrandDepartment of Forensic Genetics and Forensic Toxicology National Board of Forensic Medicine Linköping Sweden.
Martin JosefssonDepartment of Forensic Genetics and Forensic Toxicology National Board of Forensic Medicine Linköping Sweden.
Simona CalistriDepartment of Clinical Chemistry Erasmus University Medical Center Rotterdam The Netherlands.
Ron H N van SchaikDepartment of Clinical Chemistry Erasmus University Medical Center Rotterdam The Netherlands.
Henrik GreenDepartment of Forensic Genetics and Forensic Toxicology National Board of Forensic Medicine Linköping Sweden.
Fredrik C KugelbergDepartment of Forensic Genetics and Forensic Toxicology National Board of Forensic Medicine Linköping Sweden.
Linköping University · SEErasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tramadol is a complex drug, being metabolized by polymorphic enzymes and administered as a racemate with the (+)- and (-)-enantiomers of the parent compound and metabolites showing different pharmacological effects. The study aimed to simultaneously determine the enantiomer concentrations of tramadol,

Indexed as

Administration, OralAdultAnalgesics, OpioidCytochrome P-450 CYP2B6Cytochrome P-450 CYP2D6Cytochrome P-450 CYP3AGenotypeHumansStereoisomerismTramadolYoung AdultAnalgesics, OpioidCYP2B6 protein, humanCYP3A4 protein, humanCytochrome P-450 CYP2B6Cytochrome P-450 CYP2D6Cytochrome P-450 CYP3ATramadolCYP2B6CYP2D6CYP3A4enantioselective pharmacokineticstramadol

Identifiers

PMID29992026
PMCPMC6034060
OpenAlexW2829243725

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.