Evidence map›Paper›PMID 29998253›Full record

ReviewNanoscale2018

The aerolysin nanopore: from peptidomic to genomic applications.

Yong Wang, Li-Qun Gu, Kai Tian

Abstract readReview
In one paragraph

Review in Nanoscale, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Nanopore Detection Assisted DNA Information Processing.Nanomaterials (Basel, Switzerland) · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yong WangVirginia G. Piper Biodesign Center for Personalized Diagnostics, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA. ywan1012@asu.edu.ORCID http://orcid.org/0000-0002-3162-3492
Li-Qun GuDepartment of Bioengineering and Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA. gul@missouri.edu.ORCID http://orcid.org/0000-0002-8710-6160
Kai TianDepartment of Bioengineering and Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA. gul@missouri.edu.ORCID http://orcid.org/0000-0002-5543-571X

Funding

Nanopore single-molecule dielectrophoresis and biomedical detectionR01GM114204 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI GU, LI-QUN (ANDREW) · 2015 to 2017
$887k
Nanocross-nanopore for the detection of nucleic acid sequence and structureR56HG009338 · NHGRI · UNIVERSITY OF MISSOURI-COLUMBIA · PI GATES, KENT S, GU, LI-QUN (ANDREW) · 2017 to 2017
$474k
NHGRI NIH HHS R56 HG009338NIGMS NIH HHS R01 GM114204
6 · The paper itself

Abstract

The aerolysin pore (ARP) is a newly emerging nanopore that has been extensively used for peptide and protein sensing. Recently, several groups have explored the application of ARP in detecting genetic and epigenetic markers. This brief review summarizes the current applications of ARP, progressing from peptidomic to genomic detection; the recently reported site-directed mutagenesis of ARP; and new genomic DNA sensing approaches, and their advantages and disadvantages. This review will also discuss the perspectives and future applications of ARP for nucleic acid sequencing and biomolecule sensing.

Indexed as

GenomicsNanoporesBacterial ToxinsMutagenesis, Site-DirectedOligonucleotidesPore Forming Cytotoxic ProteinsProtein Structure, TertiaryaerolysinBacterial ToxinsOligonucleotidesPore Forming Cytotoxic Proteins

Identifiers

PMID29998253
PMCPMC6157726

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.