Evidence map›Paper›PMID 30002061›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2018

Cystathionine γ-Lyase Modulates Flow-Dependent Vascular Remodeling.

Shuai Yuan, Arif Yurdagul, Jonette M Peretik, Mabruka Alfaidi, Zaki Al Yafeai, Sibile Pardue, Christopher G Kevil, A Wayne Orr

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Hydrogen Sulfide Actions in the Vasculature.Comprehensive Physiology · 2021
    Article
  12. Article
  13. Biomechanical cues as master regulators of hematopoietic stem cell fate.Cellular and molecular life sciences : CMLS · 2021
    Review
  14. Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Article
  15. Vascular Mechanobiology: Homeostasis, Adaptation, and Disease.Annual review of biomedical engineering · 2021
    Review
  16. Review
  17. Review
  18. Review
  19. Endothelium as a Source and Target of HAntioxidants (Basel, Switzerland) · 2021
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shuai YuanFrom the Department of Cellular Biology and Anatomy (S.Y., A.Y., C.G.K., A.W.O.).
Arif YurdagulFrom the Department of Cellular Biology and Anatomy (S.Y., A.Y., C.G.K., A.W.O.).
Jonette M PeretikDepartment of Pathology and Translational Pathobiology (J.M.P., M.A., S.P., C.G.K., A.W.O.).
Mabruka AlfaidiDepartment of Pathology and Translational Pathobiology (J.M.P., M.A., S.P., C.G.K., A.W.O.).
Zaki Al YafeaiDepartment of Cellular and Molecular Physiology (Z.A.Y., C.G.K., A.W.O.).
Sibile PardueDepartment of Pathology and Translational Pathobiology (J.M.P., M.A., S.P., C.G.K., A.W.O.).
Christopher G KevilFrom the Department of Cellular Biology and Anatomy (S.Y., A.Y., C.G.K., A.W.O.).
A Wayne OrrFrom the Department of Cellular Biology and Anatomy (S.Y., A.Y., C.G.K., A.W.O.).
Louisiana State University Health Sciences Center Shreveport · US

Funding

Stress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Christopher G Kevil · 2018 to 2026
$23.6M
Nck Adaptor Proteins in Atherogenic Endothelial ActivationR01HL133497 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ORR, ANTHONY WAYNE · 2016 to 2024
$3.8M
Matrix Signaling in Endothelial Cell DysfunctionR01HL098435 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ORR, ANTHONY WAYNE · 2010 to 2020
$3.2M
Hydrogen sulfide and vascular remodelingR01HL113303 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI KEVIL, CHRISTOPHER G · 2012 to 2016
$1.8M
NHLBI NIH HHS R01 HL098435NHLBI NIH HHS R01 HL113303NHLBI NIH HHS R01 HL133497NIGMS NIH HHS P20 GM121307
6 · The paper itself

Abstract

Objective- Flow patterns differentially regulate endothelial cell phenotype, with laminar flow promoting vasodilation and disturbed flow promoting endothelial proinflammatory activation. CSE (cystathionine γ-lyase), a major source of hydrogen sulfide (H

Indexed as

Blood Flow VelocityAnimalsBenzoatesBiological AvailabilityCarotid ArteriesCells, CulturedCystathionine gamma-LyaseEndothelial CellsGene ExpressionHumansHydrogen SulfideImidazolesInflammationIntercellular Adhesion Molecule-1MaleMice, Inbred C57BL1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazoleBenzoatesCystathionine gamma-LyaseHydrogen SulfideImidazolesIntercellular Adhesion Molecule-1NF-kappa BNitric OxideVascular Cell Adhesion Molecule-1cystathionine gamma-lyasedisturbed flowendothelial cellshydrogen sulfideshear stressvascular remodelingvasodilation

Identifiers

PMID30002061
PMCPMC6662734
OpenAlexW2826262437

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.