Evidence map›Paper›PMID 30002490›Full record

ArticleActa pharmacologica Sinica2019

Sevoflurane postconditioning protects against myocardial ischemia/reperfusion injury by restoring autophagic flux via an NO-dependent mechanism.

Shi-Gang Qiao, Ying Sun, Bo Sun, An Wang, Jia Qiu, Lei Hong, Jian-Zhong An, Chen Wang, Hui-Ling Zhang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
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  13. Regulation of autophagy of the heart in ischemia and reperfusion.Apoptosis : an international journal on programmed cell death · 2023
    Review
  14. Cardioprotective effects of sinomenine in myocardial ischemia/reperfusion injury in a rat model.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Shi-Gang QiaoDepartment of Pharmacology and Laboratory of Cerebrovascular and Cardiovascular Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou, 215123, China.
Ying SunDepartment of Anesthesiology, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Bo SunDepartment of Anesthesiology, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
An WangDepartment of Pharmacology and Laboratory of Cerebrovascular and Cardiovascular Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou, 215123, China.
Jia QiuDepartment of Pharmacology and Laboratory of Cerebrovascular and Cardiovascular Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou, 215123, China.
Lei HongInstitute of Clinical Medicine Research, the Affiliated Suzhou Hospital of Nanjing Medical University; Suzhou Science and Technology Town Hospital, Suzhou, 215153, China.
Jian-Zhong AnInstitute of Clinical Medicine Research, the Affiliated Suzhou Hospital of Nanjing Medical University; Suzhou Science and Technology Town Hospital, Suzhou, 215153, China.
Chen WangInstitute of Clinical Medicine Research, the Affiliated Suzhou Hospital of Nanjing Medical University; Suzhou Science and Technology Town Hospital, Suzhou, 215153, China. anesthesia_chen@163.com.
Hui-Ling ZhangDepartment of Pharmacology and Laboratory of Cerebrovascular and Cardiovascular Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou, 215123, China. huilingzhang07@hotmail.com.
Soochow University · CNSecond Affiliated Hospital of Soochow University · CNSuzhou Municipal Hospital · CNNanjing Medical University · CNSuzhou University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Volatile anesthetics improve postischemic cardiac function and reduce infarction even when administered for only a brief time at the onset of reperfusion. A recent study showed that sevoflurane postconditioning (SPC) attenuated myocardial reperfusion injury, but the underlying mechanisms remain unclear. In this study, we examined the effects of sevoflurane on nitric oxide (NO) release and autophagic flux during the myocardial ischemia/reperfusion (I/R) injury in rats in vivo and ex vivo. Male rats were subjected to 30 min ischemia and 2 h reperfusion in the presence or absence of sevoflurane (1.0 minimum alveolar concentration) during the first 15 min of reperfusion. We found that SPC significantly improved hemodynamic performance after reperfusion, alleviated postischemic myocardial infarction, reduced nicotinamide adenine dinucleotide content loss, and cytochrome c release in heart tissues. Furthermore, SPC significantly increased the phosphorylation of endothelial nitric oxide synthase (NOS) and neuronal nitric oxide synthase, and elevated myocardial NOS activity and NO production. All these effects were abolished by treatment with an NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME, 10 mg/kg, i.v.). We also observed myocardial I/R-induced accumulation of autophagosomes in heart tissues, as evidenced by increased ratios of microtubule-associated protein 1 light chain 3 II/I, up-regulation of Beclin 1 and P62, and reduced lysosome-associated membrane protein-2 expression. SPC significantly attenuated I/R-impaired autophagic flux, which were blocked by L-NAME. Moreover, pretreatment with the autophagic flux blocker chloroquine (10 mg/kg, i.p.) increased autophagosome accumulation in SPC-treated heart following I/R and blocked SPC-induced cardioprotection. The same results were also observed in a rat model of myocardial I/R injury ex vivo, suggesting that SPC protects rat hearts against myocardial reperfusion injury by restoring I/R-impaired autophagic flux via an NO-dependent mechanism.

Indexed as

AnimalsAutophagyMaleMyocardial Reperfusion InjuryMyocardiumNitric OxideNitric Oxide Synthase Type INitric Oxide Synthase Type IIIRats, Sprague-DawleySevofluraneNitric OxideNitric Oxide Synthase Type INitric Oxide Synthase Type IIISevofluraneautophagychloroquinemyocardial reperfusion injuryNG-nitro-L-arginine methyl esternitric oxide; nitric oxide synthase; sevoflurane

Identifiers

PMID30002490
PMCPMC6318323
OpenAlexW2848095320

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.