Evidence map›Paper›PMID 30002646›Full record

ReviewFrontiers in endocrinology2018

Prep1, A Homeodomain Transcription Factor Involved in Glucose and Lipid Metabolism.

Francesco Oriente, Giuseppe Perruolo, Ilaria Cimmino, Serena Cabaro, Antonietta Liotti, Michele Longo, Claudia Miele, Pietro Formisano, Francesco Beguinot

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. iScience · 2025
    Article
  4. Comprehensive summary: the role of PBX1 in development and cancers.Frontiers in cell and developmental biology · 2024
    Review
  5. Long Noncoding RNAs in the Pathogenesis of Insulin Resistance.International journal of molecular sciences · 2022
    Review
  6. Article
  7. The molecular tug of war between immunity and fertility: Emergence of conserved signaling pathways and regulatory mechanisms.BioEssays : news and reviews in molecular, cellular and developmental biology · 2020
    Review
  8. Article
  9. Article
  10. The Role of Prep1 in the Regulation of Mesenchymal Stromal Cells.International journal of molecular sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Francesco OrienteDepartment of Translational Medicine, Federico II University of Naples, Naples, Italy.
Giuseppe PerruoloDepartment of Translational Medicine, Federico II University of Naples, Naples, Italy.
Ilaria CimminoDepartment of Translational Medicine, Federico II University of Naples, Naples, Italy.
Serena CabaroDepartment of Translational Medicine, Federico II University of Naples, Naples, Italy.
Antonietta LiottiDepartment of Translational Medicine, Federico II University of Naples, Naples, Italy.
Michele LongoDepartment of Translational Medicine, Federico II University of Naples, Naples, Italy.
Claudia MieleDepartment of Translational Medicine, Federico II University of Naples, Naples, Italy.
Pietro FormisanoDepartment of Translational Medicine, Federico II University of Naples, Naples, Italy.
Francesco BeguinotDepartment of Translational Medicine, Federico II University of Naples, Naples, Italy.
Institute for Experimental Endocrinology and Oncology · ITNational Research Council · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The three-amino acid loop extension (TALE) homeodomain proteins are a family of transcription factor including the mammalian Pbx, MEIS and Prep proteins. TALE proteins can bind other transcription factors such as Pdx-1 and play an important role in the regulation of glucose metabolism. Experiments performed in mutant mice have shown that while the single

Indexed as

diabetes mellitusinsulin signalingPrep1TALE proteinstranscription factors

Identifiers

PMID30002646
PMCPMC6032887
OpenAlexW2811123701

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.