Evidence map›Paper›PMID 30002917›Full record

ArticleNPJ vaccines2018

Antibody targeting of a specific region of

Gaspar E Canepa, Alvaro Molina-Cruz, Lampouguin Yenkoidiok-Douti, Eric Calvo, Adeline E Williams, Martin Burkhardt, Fangni Peng, David Narum, Martin J Boulanger, Jesus G Valenzuela and 1 more

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Current approaches to malaria vaccines.Current opinion in microbiology · 2022
    Review
  15. Review
  16. Pfs47 as a Malaria Transmission-Blocking Vaccine Target.The American journal of tropical medicine and hygiene · 2022
    Article
  17. Review
  18. Host-parasite interactions duringFrontiers in immunology · 2022
    Review
  19. Frontiers in cellular and infection microbiology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Gaspar E Canepa *1Laboratory of Malaria and Vector Research, National Insti6tute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 USA.
Alvaro Molina-Cruz *1Laboratory of Malaria and Vector Research, National Insti6tute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 USA.
Lampouguin Yenkoidiok-Douti1Laboratory of Malaria and Vector Research, National Insti6tute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 USA.
Eric Calvo1Laboratory of Malaria and Vector Research, National Insti6tute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 USA.ORCID 0000-0001-7880-2730
Adeline E Williams1Laboratory of Malaria and Vector Research, National Insti6tute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 USA.
Martin Burkhardt3Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 USA.
Fangni Peng4Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8P 5C2 Canada.
David Narum3Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 USA.
Martin J Boulanger4Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8P 5C2 Canada.
Jesus G Valenzuela1Laboratory of Malaria and Vector Research, National Insti6tute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 USA.ORCID 0000-0002-5589-9450
Carolina Barillas-Mury1Laboratory of Malaria and Vector Research, National Insti6tute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 USA.
National Institutes of Health · USUniversity of Victoria · CA

Funding

Mosquito Immune Responses and Malaria TransmissionZIAAI000947 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARILLAS-MURY, CAROLINA · 2009 to 2025
$26.2M
Molecular approaches to understand vector-host and vector-pathogen interactionsZIAAI000932 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI VALENZUELA, JESUS · 2009 to 2025
$23.1M
Arthropod saliva in vector-borne disease transmission: Functional analysis of novel domains in salivary secretionsZIAAI001246 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CALVO, ERIC · 2019 to 2025
$10.0M
Mosquito Midgut Immune Responses &Malaria TransmissionZ01AI000947 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI BARILLAS-MURY, CAROLINA · 2004 to 2008
$1.8M
Intramural NIH HHS Z01 AI000947
6 · The paper itself

Abstract

Transmission-blocking vaccines are based on eliciting antibody responses in the vertebrate host that disrupt parasite development in the mosquito vector and prevent malaria transmission. The surface protein Pfs47 is present in

Identifiers

PMID30002917
PMCPMC6039440
OpenAlexW2808217454

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.