Evidence map›Paper›PMID 30003117›Full record

ArticleMolecular therapy. Methods & clinical development2018

Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis.

Silvia Aldi, Ljubica Perisic Matic, Gregory Hamm, Daniëlle van Keulen, Dennie Tempel, Kim Holmstrøm, Agnieszka Szwajda, Boye Schnack Nielsen, Valur Emilsson, Rima Ait-Belkacem and 8 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Role of G-protein coupled receptors in cardiovascular diseases.Frontiers in cardiovascular medicine · 2023
    Review
  9. Lysophosphatidic acid receptor 6 regulated by miR-27a-3p attenuates tumor proliferation in breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Article
  10. Review
  11. Article
  12. Crossing signals: bioactive lipids in the microvasculature.American journal of physiology. Heart and circulatory physiology · 2020
    Review
  13. Article
  14. Article
  15. An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases.International journal of molecular sciences · 2019
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 4 countries.

Silvia AldiDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Sweden.
Ljubica Perisic MaticDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Sweden.
Gregory HammImaBiotech, MS Imaging Department, Loos, France.
Daniëlle van KeulenQuorics BV, Rotterdam, the Netherlands.
Dennie TempelQuorics BV, Rotterdam, the Netherlands.
Kim HolmstrømBioneer A/S, Hørsholm, Denmark.
Agnieszka SzwajdaTranslational Sciences, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Boye Schnack NielsenBioneer A/S, Hørsholm, Denmark.
Valur EmilssonIcelandic Heart Association, Kopavogur, Iceland.
Rima Ait-BelkacemImaBiotech, MS Imaging Department, Loos, France.
Mariette LengquistDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Sweden.
Gabrielle Paulsson-BerneCardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Per ErikssonCardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Jan H N LindemanDepartment of Vascular Surgery, Leiden University Medical Center, the Netherlands.
Alain J GoolTNO, Zeist, the Netherlands.
Jonathan StauberImaBiotech, MS Imaging Department, Loos, France.
Ulf HedinDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Sweden.
Eva Hurt-CamejoTranslational Sciences, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Karolinska Institutet · SEBioneer (Denmark) · DKAstraZeneca (Sweden) · SEIcelandic Heart Association · ISKarolinska University Hospital · SELeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Variants in the

Indexed as

atherosclerosisbiobank profilingtherapy

Identifiers

PMID30003117
PMCPMC6039967
OpenAlexW2810100004

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.