Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Beta-Blocker Propranolol Modulates Decision Urgency During Sequential Information Gathering.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Disentangling the roles of dopamine and noradrenaline in the exploration-exploitation tradeoff during human decision-making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Neurophysiological contributors to advantageous risk-taking: an experimental psychopharmacological investigation.Social cognitive and affective neuroscience · 2021Trial
- The Computational, Pharmacological, and Physiological Determinants of Sensory Learning under Uncertainty.Current biology : CB · 2021Trial
- Distinct Roles of Dopamine and Noradrenaline in Incidental Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Trial
- Regulation of the decision threshold by the locus coeruleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Indecision and recency-weighted evidence integration in non-clinical and clinical settings.Nature human behaviour · 2026Article
- Active information sampling in health and disease.Neuroscience and biobehavioral reviews · 2025Review
- Meta-Reinforcement Learning reconciles surprise, value, and control in the anterior cingulate cortex.PLoS computational biology · 2025Article
- Boosting Serotonin Increases Information Gathering by Reducing Subjective Cognitive Costs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Movement characteristics impact decision-making and vice versa.Scientific reports · 2023Article
- The promise of a model-based psychiatry: building computational models of mental ill health.The Lancet. Digital health · 2022Review
- Freezing revisited: coordinated autonomic and central optimization of threat coping.Nature reviews. Neuroscience · 2022Review
- Hasty sensorimotor decisions rely on an overlap of broad and selective changes in motor activity.PLoS biology · 2022Article
- Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- The effect of ambient sounds on decision-making and heart rate variability in autism.Autism : the international journal of research and practice · 2021Article
- The computational cost of active information sampling before decision-making under uncertainty.Nature human behaviour · 2021Article
- Article
- Human complex exploration strategies are enriched by noradrenaline-modulated heuristics.eLife · 2021Article
- Motor cortex disruption delays motor processes but not deliberation about action choices.Journal of neurophysiology · 2019Article
- Looking for Mr(s) Right: Decision bias can prevent us from finding the most attractive face.Cognitive psychology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Arbitrating between timely choice and extended information gathering is critical for effective decision making. Aberrant information gathering behavior is thought to be a feature of psychiatric disorders such as schizophrenia and obsessive-compulsive disorder, but we know little about the underlying neurocognitive control mechanisms. In a double-blind, placebo-controlled drug study involving 60 healthy human subjects (30 female), we examined the effects of noradrenaline and dopamine antagonism on information gathering during performance of an information sampling task. We show that modulating noradrenaline function with 40 mg of the β-blocker propranolol leads to decreased information gathering behavior. Modulating dopamine function via a single dose of 400 mg of amisulpride revealed some effects that were intermediate between those of propranolol and placebo. Using a Bayesian computational model, we show that sampling behavior is best explained by inclusion of a nonlinear urgency signal that promotes commitment to an early decision. Noradrenaline blockade promotes the expression of this decision-related urgency signal during information gathering. We discuss the findings with respect to psychopathological conditions that are linked to aberrant information gathering.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.