ArticleOncology letters2018
Cross talk of chromosome instability, CpG island methylator phenotype and mismatch repair in colorectal cancer.
Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
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- Application of low-coverage whole-genome sequencing technology in risk stratification of colorectal adenomas.Frontiers in oncology · 2025Article
- Integration of gene expression data identifies key genes and pathways in colorectal cancer.Medical oncology (Northwood, London, England) · 2021Article
- Review
- Identification of Post-myocardial Infarction Blood Expression Signatures Using Multiple Feature Selection Strategies.Frontiers in physiology · 2020Article
- Investigation and Prediction of Human Interactome Based on Quantitative Features.Frontiers in bioengineering and biotechnology · 2020Article
- Identification of Gene Signatures and Expression Patterns During Epithelial-to-Mesenchymal Transition From Single-Cell Expression Atlas.Frontiers in genetics · 2020Article
- Identifying Methylation Pattern and Genes Associated with Breast Cancer Subtypes.International journal of molecular sciences · 2019Article
- Cross-platform Data Analysis Reveals a Generic Gene Expression Signature for Microsatellite Instability in Colorectal Cancer.BioMed research international · 2019Article
- The transcriptome difference between colorectal tumor and normal tissues revealed by single-cell sequencing.Journal of Cancer · 2019Article
- Identifying Microbiota Signature and Functional Rules Associated With Bacterial Subtypes in Human Intestine.Frontiers in genetics · 2019Article
- Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas.Frontiers in bioengineering and biotechnology · 2019Article
- Identification and Analysis of Blood Gene Expression Signature for Osteoarthritis With Advanced Feature Selection Methods.Frontiers in genetics · 2018Article
- Identification of the predictive genes for the response of colorectal cancer patients to FOLFOX therapy.OncoTargets and therapy · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer is a severe cancer associated with a high prevalence and fatality rate. There are three major mechanisms for colorectal cancer: (1) Chromosome instability (CIN), (2) CpG island methylator phenotype (CIMP) and (3) mismatch repair (MMR), of which CIN is the most common type. However, these subtypes are not exclusive and overlap. To investigate their biological mechanisms and cross talk, the gene expression profiles of 585 colorectal cancer patients with CIN, CIMP and MMR status records were collected. By comparing the CIN+ and CIN-samples, CIMP+ and CIMP-samples, MMR+ and MMR-samples with minimal redundancy maximal relevance (mRMR) and incremental feature selection (IFS) methods, the CIN, CIMP and MMR associated genes were selected. Unfortunately, there was little direct overlap among them. To investigate their indirect interactions, downstream genes of CIN, CIMP and MMR were identified using the random walk with restart (RWR) method and a greater overlap of downstream genes was indicated. The common downstream genes were involved in biosynthetic and metabolic pathways. These findings were consistent with the clinical observation of wide range metabolite aberrations in colorectal cancer. To conclude, the present study gave a gene level explanation of CIN, CIMP and MMR, but also showed the network level cross talk of CIN, CIMP and MMR. The common genes of CIN, CIMP and MMR may be useful for cross-subtype general colorectal cancer drug development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.