Evidence map›Paper›PMID 30018039›Full record

ArticleThe Journal of general physiology2018

Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites.

Yali Wang, Elaine Yang, Marta M Wells, Vasyl Bondarenko, Kellie Woll, Vincenzo Carnevale, Daniele Granata, Michael L Klein, Roderic G Eckenhoff, William P Dailey and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Propofol inhibits prokaryotic voltage-gated NaThe Journal of general physiology · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Yali WangDepartment of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Elaine YangDepartment of Neuroscience and Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College and Jefferson College of Biomedical Sciences, Thomas Jefferson University, Philadelphia, PA.ORCID 0000-0001-5158-9909
Marta M WellsDepartment of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Vasyl BondarenkoDepartment of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Kellie WollDepartment of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA.
Vincenzo CarnevaleInstitute for Computational Molecular Science, College of Science and Technology, Temple University, Philadelphia, PA.ORCID 0000-0002-1918-8280
Daniele GranataInstitute for Computational Molecular Science, College of Science and Technology, Temple University, Philadelphia, PA.
Michael L KleinInstitute for Computational Molecular Science, College of Science and Technology, Temple University, Philadelphia, PA.
Roderic G EckenhoffDepartment of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA.
William P DaileyDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-5554-6698
Manuel CovarrubiasDepartment of Neuroscience and Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College and Jefferson College of Biomedical Sciences, Thomas Jefferson University, Philadelphia, PA.ORCID 0000-0002-0881-4143
Pei TangDepartment of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Yan XuDepartment of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA xuy@anes.upmc.edu.ORCID 0000-0003-2773-8024
University of Pittsburgh · USTemple University · USUniversity of Pennsylvania · USThomas Jefferson University · US

Funding

X-ray and Neutron Interferometry Studies of Anesthetic Interactions with VoltageP01GM055876 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LOLL, PATRICK J · 1997 to 2017
$22.4M
ANESTHETIC SITES IN TRANSMEMBRANE PEPTIDES BY NMRR01GM056257 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TANG, PEI · 1998 to 2017
$4.8M
NMR STUDIES OF MECHANISMS OF GENERAL ANESTHESIAR01GM049202 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XU, YAN · 2000 to 2018
$3.3M
Molecular Basis of General Anesthetic Action on Voltage-Gated Sodium ChannelsF30GM123612 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI YANG, ELAINE · 2017 to 2019
$133k
NIGMS NIH HHS F30 GM123612NIGMS NIH HHS P01 GM055876NIGMS NIH HHS R01 GM049202NIGMS NIH HHS R01 GM056257
6 · The paper itself

Abstract

Voltage-gated sodium (Na

Indexed as

AnimalsBacterial ProteinsFluorineHEK293 CellsHumansHypnotics and SedativesLarvaMagnetic Resonance SpectroscopyPatch-Clamp TechniquesPropofolSodium ChannelsXenopus laevisBacterial ProteinsFluorineHypnotics and SedativesNaChBac protein, bacteriaPropofolSodium Channels

Identifiers

PMID30018039
PMCPMC6122922
OpenAlexW2883011012

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.