Evidence map›Paper›PMID 30020212›Full record

ArticleJournal of occupational and environmental medicine2018

Systemic Effects of Segmental Vibration in an Animal Model of Hand-Arm Vibration Syndrome.

Kristine Krajnak, Stacy Waugh

Abstract read
In one paragraph

Article in Journal of occupational and environmental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Serum Metabolites in Hand-Arm Vibration Exposed Workers.Journal of occupational and environmental medicine · 2020
    Article
  7. Article
  8. Health effects associated with occupational exposure to hand-arm or whole body vibration.Journal of toxicology and environmental health. Part B, Critical reviews · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kristine KrajnakEngineering Controls and Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, Washington.
Stacy Waugh

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

objectiveEpidemiology suggests that occupational exposure to hand-transmitted (segmental) vibration has local and systemic effects. This study used an animal model of segmental vibration to characterize the systemic effects of vibration.

methodsMale Sprague Dawley rats were exposed to tail vibration for 10 days. Genes indicative of inflammation, oxidative stress, and cell cycle, along were measured in the heart, kidney, prostate, and liver.

resultsVibration increased oxidative stress and pro-inflammatory gene expression, and decreased anti-oxidant enzymes in heart tissue. In the prostate and liver, vibration resulted in changes in the expression of pro-inflammatory factors and genes involved in cell cycle regulation.

conclusionsThese changes are consistent with epidemiological studies suggesting that segmental vibration has systemic effects. These effects may be mediated by changes in autonomic nervous system function, and/or inflammation and oxidative stress.

Indexed as

Gene ExpressionAnimalsCell CycleDisease Models, AnimalHand-Arm Vibration SyndromeInflammationKidneyLiverMaleMyocardiumNitrous OxideOxidative StressPressureProstateRatsRats, Sprague-DawleyNitrous OxideReactive Oxygen SpeciesRNA

Identifiers

PMID30020212
PMCPMC6173648

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.