Evidence map›Paper›PMID 30030171›Full record

ArticlePharmacological research2019

Gut-derived serotonin contributes to bone deficits in colitis.

B Lavoie, J A Roberts, M M Haag, S N Spohn, K G Margolis, K A Sharkey, J B Lian, G M Mawe

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Gut microbiome and bone health: update on mechanisms, clinical correlations, and possible treatment strategies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Pooled it
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  9. The IL-18 receptor is expressed on murine small-intestinal enterochromaffin cells and executes a recovery program upon injury.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Review
  11. Article
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  13. Article
  14. The enteric nervous system.Physiological reviews · 2023
    Review
  15. Review
  16. The potential mechanism of the microbiota-gut-bone axis in osteoporosis: a review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Review
  17. Article
  18. Perspective on skeletal health in inflammatory bowel disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

B LavoieDepartment of Neurological Sciences, The University of Vermont, Burlington, VT, USA. Electronic address: blavoie@uvm.edu.
J A RobertsDepartment of Neurological Sciences, The University of Vermont, Burlington, VT, USA.
M M HaagDepartment of Neurological Sciences, The University of Vermont, Burlington, VT, USA.
S N SpohnDepartment of Neurological Sciences, The University of Vermont, Burlington, VT, USA.
K G MargolisDepartment of Pediatrics, Columbia University, New York, NY, USA.
K A SharkeyDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.
J B LianDepartment of Biochemistry, The University of Vermont, Burlington, VT, USA.
G M MaweDepartment of Neurological Sciences, The University of Vermont, Burlington, VT, USA.
University of Vermont · USColumbia University · USUniversity of Calgary · CA

Funding

Synthesis of Osteocalcin in BoneR37DE012528 · NIDCR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIAN, JANE B. · 2008 to 2017
$5.0M
Neuronal Excitability and Motility in ColitisR01DK062267 · NIDDK · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI MAWE, GARY M · 2002 to 2016
$3.3M
Synthesis of Osteocalcin in BoneR56DE012528 · NIDCR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LIAN, JANE B., STEIN, GARY S. · 2018 to 2018
$427k
NIDCR NIH HHS R37 DE012528NIDCR NIH HHS R56 DE012528NIDDK NIH HHS R01 DK062267
6 · The paper itself

Abstract

Osteoporosis and bone fractures occur at higher frequency in patients with inflammatory bowel disease (IBD), and decreased bone mass is observed in animal models of colitis. Another consistent feature of colitis is increased serotonin (5-HT) availability in the intestinal mucosa. Since gut-derived 5-HT can decrease bone mass, via activation of 5-HT

Indexed as

AnimalsBone ResorptionColitisDextran SulfateFemurIntestinal MucosaMaleMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutSerotoninSerotonin Plasma Membrane Transport ProteinsX-Ray MicrotomographyDextran SulfateSerotoninSerotonin Plasma Membrane Transport Proteins5-HT(1B) receptorbone lossDSS-induced colitisPeripheral 5-HT

Identifiers

PMID30030171
PMCPMC6336528
OpenAlexW2883211179

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.