ArticleJournal of advanced research2018
Formulation and evaluation of pH-sensitive rutin nanospheres against colon carcinoma using HCT-116 cell line.
Article in Journal of advanced research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Pooled it
- Polyphenol-Based Nanomedicine: Versatile Platforms for Immune Modulation and Therapeutic Delivery.Molecules (Basel, Switzerland) · 2026Review
- Advances in NP shapes and their applications in cancer therapy.RSC advances · 2026Review
- A Comprehensive Analysis of Natural Bioactive Molecules for the Treatment and Control of Glioblastoma Multiforme (GBM) Targeting Underlying Molecular Mechanism.Chemistry & biodiversity · 2026Review
- Characterization of enteric-coated capsules filled with colchicine loaded zein nanoparticles for colon delivery.Therapeutic delivery · 2025Article
- Current strategies for rutin nano-formulation; a promising bioactive compound with increased efficacy.Bioprocess and biosystems engineering · 2025Review
- Microencapsulation of Deer Oil in Soy Protein Isolate-Chitosan Complex Coacervate-Preparation, Characterization, and Simulated Digestion.Foods (Basel, Switzerland) · 2025Article
- Spray-Dried Powders of Casein-Encapsulated Rutin Stabilized With Sugars for the Enhancement of Intestinal Drug Solubility.Advances in pharmacological and pharmaceutical sciences · 2025Article
- Developing and Applying a Single Strategy for Improved Intestinal Permeability of Diverse and Complex Phytomolecules: Nanoformulations of Rutin, Quercetin, Thymoquinone Provide Proof-of-Concept.Advanced pharmaceutical bulletin · 2024Article
- Bioactive Potential of Chitosan-Oleic Acid Nanoparticles Loaded with Lemon Peel Essential Oil for Topical Treatment of Vulvovaginal Candidiasis.Molecules (Basel, Switzerland) · 2024Article
- Rutin loaded bilosomes for enhancing the oral activity and nephroprotective effects of rutin in potassium dichromate induced acute nephrotoxicity in rats.Scientific reports · 2024Article
- Appraisal terpenoids rich Boswellia carterri ethyl acetate extract in binary cyclodextrin oligomer nano complex for improving respiratory distress.Scientific reports · 2024Article
- Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats.Scientific reports · 2024Article
- Study of PEG-ACS omega · 2024Article
- Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish.Environmental health perspectives · 2024Article
- Nanoparticle-Based Drug Delivery Systems for Inflammatory Bowel Disease Treatment.Drug design, development and therapy · 2024Review
- Rutin alleviates colon lesions and regulates gut microbiota in diabetic mice.Scientific reports · 2023Article
- An Innovative Approach for Formulation of Rutin Tablets Targeted for Colon Cancer Treatment.AAPS PharmSciTech · 2023Article
- Thymol-Loaded Eudragit RS30D Cationic Nanoparticles-Based Hydrogels for Topical Application in Wounds: In Vitro and In Vivo Evaluation.Pharmaceutics · 2022Article
- Quercitrin loaded cyclodextrin based nanosponge as a promising approach for management of lung cancer and COVID-19.Journal of drug delivery science and technology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to target rutin, in a more solubilized form, to the colon aiming at treatment of colon carcinoma. pH sensitive nanospheres were prepared by the nanoprecipitation technique employing Eudragit S100. Different drug: polymer ratios as well as different concentrations of the stabilizer Poloxamer-188 were used. The developed rutin nanospheres exhibited entrapment efficiency ranging from 94.19% to 98.1%, with a zeta potential values <-20 mV. They were spherical in shape and their sizes were in the nanometric dimensions. The
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.