Evidence map›Paper›PMID 30035339›Full record

Trial reportInternational journal of geriatric psychiatry2018

Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder.

Jeffrey N Motter, Gregory H Pelton, Kristina D'Antonio, Sara N Rushia, Monique A Pimontel, Jeffrey R Petrella, Ernst Garcon, Michaela W Ciovacco, Joel R Sneed, P Murali Doraiswamy and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of geriatric psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06601933 (Cognitive Training and Neuroplasticity in Mild Cognitive Impairment), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06601933 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial

TypeinterventionalSponsorColumbia UniversityRan2024 to 2030Enrolled240ConditionsMild Cognitive Impairment (MCI), Cognitive TrainingArmsCognitive Training
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Models of depressive pseudoamnestic disorder.Alzheimer's & dementia (New York, N. Y.) · 2022
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jeffrey N MotterThe Graduate Center, City University of New York, New York, NY, USA.ORCID 0000-0002-7372-3424
Gregory H PeltonColumbia University, New York, NY, USA.
Kristina D'AntonioColumbia University, New York, NY, USA.
Sara N RushiaThe Graduate Center, City University of New York, New York, NY, USA.
Monique A PimontelThe Graduate Center, City University of New York, New York, NY, USA.ORCID 0000-0003-2775-7735
Jeffrey R PetrellaDuke University, Durham, NC, USA.
Ernst GarconColumbia University, New York, NY, USA.
Michaela W CiovaccoColumbia University, New York, NY, USA.
Joel R SneedThe Graduate Center, City University of New York, New York, NY, USA.
P Murali DoraiswamyDuke University, Durham, NC, USA.
Davangere P DevanandColumbia University, New York, NY, USA.

Funding

Pilot Combination Treatment Trial of Mild Cognitive Impairment with DepressionR01AG040093 · NIA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DEVANAND, DAVANGERE P · 2011 to 2013
$2.0M
NIA NIH HHS R01 AG040093
6 · The paper itself

Abstract

objectiveThe classification of mild cognitive impairment (MCI) continues to be debated though it has recently been subtyped into late (LMCI) versus early (EMCI) stages. Older adults presenting with both a depressive disorder (DEP) and cognitive impairment (CI) represent a unique, understudied population. Our aim was to examine baseline characteristics of DEP-CI patients in the DOTCODE trial, a randomized controlled trial of open antidepressant treatment for 16 weeks followed by add-on donepezil or placebo for 62 weeks. METHODS/

designKey inclusion criteria were diagnosis of major depression or dysthymic disorder with Hamilton Depression Rating Scale (HAM-D) score >14, and cognitive impairment defined by MMSE score ≥21 and impaired performance on the WMS-R Logical Memory II test. Patients were classified as EMCI or LMCI based on the 1.5 SD cutoff on tests of verbal memory, and compared on baseline clinical, neuropsychological, and anatomical characteristics.

resultsSeventy-nine DEP-CI patients were recruited of whom 39 met criteria for EMCI and 40 for LMCI. The mean age was 68.9, and mean HAM-D was 23.0. Late mild cognitive impairment patients had significantly worse ADAS-Cog (P < .001), MMSE (P = .004), Block Design (P = .024), Visual Rep II (P = .006), CFL Animal (P = .006), UPSIT (P = .051), as well as smaller right hippocampal volume (P = .037) compared to EMCI patients. MRI indices of cerebrovascular disease did not differ between EMCI and LMCI patients.

conclusionsCognitive and neuronal loss markers differed between EMCI and LMCI among patients with DEP-CI, with LMCI being more likely to have the clinical and neuronal loss markers known to be associated with Alzheimer's disease.

Indexed as

Cognitive DysfunctionDepressive DisorderAgedAged, 80 and overAge of OnsetAntidepressive AgentsCholinesterase InhibitorsComorbidityDonepezilFemaleHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsAntidepressive AgentsCholinesterase InhibitorsDonepezildepressionearly mild cognitive impairmentlate mild cognitive impairment

Identifiers

PMID30035339
PMCPMC6246783

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.