Evidence map›Paper›PMID 30038469›Full record

Trial reportWorld journal of gastroenterology2018

New fecal test for non-invasive

Andrea Iannone, Floriana Giorgio, Francesco Russo, Giuseppe Riezzo, Bruna Girardi, Maria Pricci, Suetonia C Palmer, Michele Barone, Mariabeatrice Principi, Giovanni Fm Strippoli and 2 more

2 registry-linked trialsOpen access · hybridAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04107194 phase3unknown statusnot on this mapstarted 2020, after this paper: background citation

Comparison Between Tailored Therapy Guided by a Non-invasive Antibiotic Susceptibility Test and Empiric Treatment for First-line Helicobacter Pylori Eradication in Patients With Dyspepsia: a Randomized Controlled Trial.

TypeinterventionalSponsorUniversity of BariRan2020 to 2022Enrolled362ConditionsHelicobacter Pylori Infection, Antibiotic Resistant Infection, Antibiotic Resistant StrainArmsPantoprazole 40mg, Amoxicillin 1000 MG, Clarithromycin 500mg, Metronidazole, Tetracycline 125 MG
NCT07293910 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Safety and Efficacy of Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori Infection

TypeinterventionalSponsorTanta UniversityRan2026 to 2026Enrolled66ConditionsHELICOBACTER PYLORI INFECTIONS, Helicobacter Infection, Helicobacter Pylori Gastrointestinal Tract Infection, Helicobacter Pylori Infected PatientsArmsVonoparazan, Vitamin D, Probiotic, Amoxicillin, Clarithromycin 500 mg
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 43 citations in OpenAlex.

  1. Clinical validation of a fecal PCR assay forJournal of clinical microbiology · 2026
    Observational
  2. Article
  3. Article
  4. Review
  5. Article
  6. Overcoming antibiotic-resistantWorld journal of gastroenterology · 2025
    Review
  7. Antibiotics (Basel, Switzerland) · 2024
    Article
  8. Clinical evaluation of a real-time PCR assay for diagnosis ofInternational journal of clinical and experimental pathology · 2024
    Article
  9. International journal of molecular sciences · 2023
    Review
  10. The State of the Art of Molecular Fecal Investigations forInternational journal of molecular sciences · 2023
    Review
  11. Article
  12. Observational
  13. What Is New inJournal of clinical medicine · 2021
    Review
  14. Polymerase chain reaction-based tests for detectingWorld journal of clinical cases · 2021
    Article
  15. Article
  16. Molecular Detection of Antibiotic-Resistant Helicobacter pylori.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  17. Antibiotics (Basel, Switzerland) · 2020
    Article
  18. Article
  19. The Puzzle of Coccoid Forms ofAntibiotics (Basel, Switzerland) · 2020
    Review
  20. Update on the Management ofCurrent treatment options in gastroenterology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Andrea IannoneSection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy.
Floriana GiorgioTHD SpA, Correggio (Reggio Emilia) 42015, Italy.
Francesco RussoNational Institute of Gastroenterology, "S De Bellis" Research Hospital, CastellanaGrotte (Bari) 70013, Italy.
Giuseppe RiezzoNational Institute of Gastroenterology, "S De Bellis" Research Hospital, CastellanaGrotte (Bari) 70013, Italy.
Bruna GirardiTHD SpA, Correggio (Reggio Emilia) 42015, Italy.
Maria PricciTHD SpA, Correggio (Reggio Emilia) 42015, Italy.
Suetonia C PalmerDepartment of Medicine, University of Otago Christchurch, Christchurch 8011, New Zealand.
Michele BaroneSection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy.
Mariabeatrice PrincipiSection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy.
Giovanni Fm StrippoliDiaverum Academy, Lund 22229, Sweden.
Alfredo Di LeoSection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy.
Enzo IerardiSection of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy. e.ierardi@virgilio.it.
University of Bari Aldo Moro · ITUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess the diagnostic accuracy of a new fecal test for detecting

methodsWe conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of

resultsWe enrolled 294 consecutive participants (age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninety-five (32.3%) participants had a positive

conclusionThe THD fecal test has high performance for the non-invasive diagnosis of

Indexed as

AdultAnti-Bacterial AgentsBreath TestsClarithromycinCross-Sectional StudiesDNA, BacterialDrug Resistance, BacterialFecesFemaleHelicobacter InfectionsHelicobacter pyloriHumansLevofloxacinMaleMiddle AgedPoint MutationAnti-Bacterial AgentsClarithromycinDNA, BacterialLevofloxacin23S rRNAAntibiotic resistanceDiagnostic accuracyFecal testFecesHelicobacter pyloriMolecular analysisStools

Identifiers

PMID30038469
PMCPMC6054951
OpenAlexW2884472086

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.