Evidence map›Paper›PMID 30043439›Full record

Observational studyInternal medicine journal2018

Human immunodeficiency virus-infected young people in Australia: data from the Australian HIV Observational Database.

Carly Hughes, Rainer Puhr, Samar Ojaimi, Kathy Petoumenos, Adam W Bartlett, David J Templeton, Catherine C O'Connor, Manoji Gunathilake, Ian Woolley

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Internal medicine journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carly HughesMonash Infectious Diseases, Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia.
Rainer PuhrThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Samar OjaimiMonash Infectious Diseases, Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia.
Kathy PetoumenosThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Adam W BartlettThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
David J TempletonThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Catherine C O'ConnorThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Manoji GunathilakeThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Ian WoolleyMonash Infectious Diseases, Monash Medical Centre, Monash Health, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0003-2928-1291

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
Australian Government Department of HealthBoehringer IngelheimBristol-Myers SquibbGilead SciencesJanssen-CilagMerck Sharp & DohmeNational Cancer InstituteNational Institute of Mental HealthNational Institute on Drug AbuseNIAID NIH HHS U01 AI069907the Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentU.S. National Institutes of Health's National Institute of Allergy and Infectious Diseases U01AI069907ViiV Healthcare
6 · The paper itself

Abstract

backgroundIndividuals aged 13-24 years undergo vast physical, cognitive, social and psychological changes. Australian data regarding clinical outcomes of those diagnosed with HIV in this age are sparse.

aimWe aimed to describe demographic factors, virologic and clinical outcomes of individuals aged 13-24 years diagnosed with human immunodeficiency virus (HIV).

methodsPatients diagnosed with HIV after 1997 in the Australian HIV Observational Database were divided into young adults, diagnosed at age <25 years (n = 223), and older adults (n = 1957). Demographic and clinical factors were compared between groups.

resultsYoung adults had a median age at diagnosis of 22 years (inter quartile range (IQR) 20-24) and median age at treatment initiation of 24 years (IQR 22-26). They were more likely to be female than the older cohort (21.1 vs 10.8%; P < 0.001). Men who have sex with men was the most common exposure category in both groups. CD4 count at diagnosis was significantly higher in younger than older adults (median 460 vs 400 cells/mm

conclusionsYoung adults were diagnosed with HIV at higher CD4 counts and lower viral loads than their older counterparts. LTFU and treatment interruption were more common highlighting the need for extra efforts directed towards retention in care and education regarding the risks of treatment interruptions.

Indexed as

HIV InfectionsAdolescentAdultAnti-HIV AgentsAustraliaCD4 Lymphocyte CountDatabases, FactualFemaleHIVHumansMaleNeeds AssessmentPatient Education as TopicViral LoadAnti-HIV Agentsadolescentepidemiologyhuman immunodeficiency virusyoung adult

Identifiers

PMID30043439
PMCPMC6281768

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.