Evidence map›Paper›PMID 30051163›Full record

ReviewCellular and molecular life sciences : CMLS2018

Cellular mechanisms and signals that coordinate plasma membrane repair.

Adam Horn, Jyoti K Jaiswal

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Sorcin couples Annexin A11 recruitment to ESCRT-III assembly for plasma membrane repair.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Orai1 is required for CabioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Revisiting the role of Annexins in membrane trafficking.Cellular and molecular life sciences : CMLS · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Adam HornCenter for Genetic Medicine Research, Children's National Health System, 111 Michigan Avenue, NW, Washington, DC, 20010-2970, USA.
Jyoti K JaiswalCenter for Genetic Medicine Research, Children's National Health System, 111 Michigan Avenue, NW, Washington, DC, 20010-2970, USA. jkjaiswal@cnmc.org.ORCID http://orcid.org/0000-0002-5992-5185

Funding

Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI GIOIA, GERARD A. · 2016 to 2020
$5.9M
Understanding the mechanism and role of cell membrane repair in Miyoshi MyopathyR01AR055686 · NIAMS · ROCKEFELLER UNIVERSITY · PI JAISWAL, JYOTI K · 2008 to 2021
$3.6M
National Institute of Child Health and Human Development U54HD090257NIAMS NIH HHS R01 AR055686NIAMS NIH HHS R01AR055686NICHD NIH HHS U54 HD090257
6 · The paper itself

Abstract

Plasma membrane forms the barrier between the cytoplasm and the environment. Cells constantly and selectively transport molecules across their plasma membrane without disrupting it. Any disruption in the plasma membrane compromises its selective permeability and is lethal, if not rapidly repaired. There is a growing understanding of the organelles, proteins, lipids, and small molecules that help cells signal and efficiently coordinate plasma membrane repair. This review aims to summarize how these subcellular responses are coordinated and how cellular signals generated due to plasma membrane injury interact with each other to spatially and temporally coordinate repair. With the involvement of calcium and redox signaling in single cell and tissue repair, we will discuss how these and other related signals extend from single cell repair to tissue level repair. These signals link repair processes that are activated immediately after plasma membrane injury with longer term processes regulating repair and regeneration of the damaged tissue. We propose that investigating cell and tissue repair as part of a continuum of wound repair mechanisms would be of value in treating degenerative diseases.

Indexed as

AnimalsCalciumCalcium-Binding ProteinsCell MembraneHumansPhospholipasesReactive Oxygen Speciesrho GTP-Binding ProteinsSignal TransductionTransient Receptor Potential ChannelsCalciumCalcium-Binding ProteinsPhospholipasesReactive Oxygen Speciesrho GTP-Binding ProteinsTransient Receptor Potential ChannelsCalciumCell membraneInjuryLipidsRedoxTissue repair

Identifiers

PMID30051163
PMCPMC6541445

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.