Evidence mapPaperPMID 30054343Full record

ArticleJournal of lipid research2018

Fatty liver disrupts glycerol metabolism in gluconeogenic and lipogenic pathways in humans.

Eunsook S Jin, Jeffrey D Browning, Rebecca E Murphy, Craig R Malloy

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

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  15. Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Eunsook S JinAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390. Electronic address: eunsook.jin@utsouthwestern.edu.
Jeffrey D BrowningAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Rebecca E MurphyAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Craig R MalloyAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390; Veterans Affairs North Texas Health Care System, Dallas, TX 75216.
Southwestern Medical Center · USVA North Texas Health Care System · US

Funding

SPECIFIC GENE AND SMALL MOLECULE DELIVERY TO CELLSP01DK058398 · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · 2000 to 2005
$6.9M
NIBIB NIH HHS P41 EB015908NIDDK NIH HHS P01 DK058398NIDDK NIH HHS R01 DK099289
6 · The paper itself

Abstract

It is a challenge to assess metabolic dysregulation in fatty liver of human patients prior to clinical manifestations. Here, we recruited obese, but otherwise healthy, subjects to examine biochemical processes in the liver with simple triglyceride accumulation using stable isotopes and NMR analysis of metabolic products in blood. Intrahepatic triglycerides were measured using

Indexed as

GluconeogenesisLipogenesisAdultFatty LiverFemaleGlycerolHumansMaleMiddle AgedYoung AdultGlycerolglucosenonalcoholic fatty liver diseasenuclear magnetic resonancetricarboxylic acid cycletriglycerides

Identifiers

PMID30054343
PMCPMC6121920
OpenAlexW2883494175

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.