ReviewWorld journal of pediatrics : WJP2018
Kaposiform hemangioendothelioma in children: a benign vascular tumor with multiple treatment options.
Review in World journal of pediatrics : WJP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04448873 (Guided Discontinuation Versus Maintenance Treatment of Sirolimus in Pediatric Patients With Kaposiform Hemangioendothelioma), which is not on this map. Cited by 46 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Guided Discontinuation Versus Maintenance Treatment of Sirolimus in Pediatric Patients With Kaposiform Hemangioendothelioma: a Randomized Controlled Trial
Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Japanese Clinical Practice Guidelines for Vascular Tumors, Vascular Malformations, Lymphatic Malformations, and Lymphangiomatosis 2022.The Journal of dermatology · 2026Guideline
- Japanese clinical practice guidelines for vascular tumors, vascular malformations, lymphatic malformations, and lymphangiomatosis 2022.Japanese journal of radiology · 2026Guideline
- Japanese clinical practice guidelines for vascular tumors, vascular malformations, lymphatic malformations, and lymphangiomatosis 2022.Surgery today · 2026Guideline
- Japanese clinical practice guidelines for vascular tumors, vascular malformations, lymphatic malformations, and Lymphangiomatosis 2022.Pediatrics international : official journal of the Japan Pediatric SocietyGuideline
- Antibody levels and immune memory in children with kaposiform hemangioendothelioma treated with sirolimus after catch up vaccination.Human vaccines & immunotherapeutics · 2026Article
- Radiofrequency ablation for severe hemangiomas with thrombocytopenia and coagulation abnormalities (Kasabach-Merritt phenomenon).Translational pediatrics · 2026Article
- Management of Kaposiform Haemangioendothelioma-A Retrospective Case Series Examining the Use and Effectiveness of Vincristine.Journal of paediatrics and child health · 2026Article
- Sirolimus to the rescue: rapid therapeutic response in kaposiform hemangioendothelioma - case report and literature overview.BMC pediatrics · 2026Review
- Unilateral endonasal kaposiform haemangioendothelioma in a newborn - a case report.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Kaposiform hemangioendothelioma: Diagnosis and treatment.Pediatric investigation · 2026Review
- Japanese Clinical Practice Guidelines for Vascular Tumors, Vascular Malformations, Lymphatic Malformations, and Lymphangiomatosis 2022.Journal of plastic and reconstructive surgery · 2026Review
- Immunological and clinical characteristics of severe thrombocytopenia in neonates with Kasabach-Merritt phenomenon.Frontiers in immunology · 2026Article
- MRI and MDCT Findings of Kaposiform Hemangioendothelioma in the Oral Cavity of a Neonate: A Case Report and Literature Review.Current medical imaging · 2026Review
- The VASCERN-VASCA diagnostic and management pathways for kaposiform hemangioendothelioma.European journal of pediatrics · 2025Article
- An adult case of thrombocytopenia associated with posterior mediastinal hemangioma suggestive of Kasabach-Merritt phenomenon with uncertain diagnosis.The Journal of international medical research · 2025Article
- Kaposiform hemangioendothelioma in the mandibular gingiva: a rare case report with literature review.Oral radiology · 2025Review
- Article
- Ultrasound-Guided Percutaneous Sclerotherapy With Bleomycin for Management of Infantile Subcutaneous Hemangioma: A Case Report.Clinical case reports · 2025Article
- Similarities and differences in the clinical features and management of primary lymphedema and kaposiform hemangioendothelioma associated with lymphedema in children.Frontiers in pediatrics · 2025Article
- Kaposiform hemangioendothelioma presented with raynaud phenomenon: a case report.BMC pediatrics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKaposiform hemangioendothelioma (KHE) is a rare vascular tumor affecting infants and young children. Although benign, it can be associated with an aggressive locally growing tumor and/or a life-threatening Kasabach-Merritt phenomenon (KMP). To date, only reviews of limited cases have been performed. We, therefore, conducted a comprehensive literature search to collect relevant data and make recommendations for future treatment trials.
methodsReview of the available literature between 1993 and 2017 revealed a total of 105 publications involving 215 patients of less than 21 years of age. To this, we added 12 from our department and 4 from the Cooperative Weichteilsarkomstudie database.
resultsWe found that KMP was present in 79% of the infants, in 47% of the 1-5-year olds, in 43% of the 6-12-year olds, and in 10% of the 13-21-year-old patients. KMP was present in nearly all (94%) patients with retroperitoneal tumors and in all patients with extra-regional tumors. The median size of a KHE without KMP was 12 cm
conclusionsPatients with progressive KHE should undergo resection whenever it is considered a safe option. If inoperable, sirolimus should be the first choice for treating KMP and reducing tumor size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.