Evidence map›Paper›PMID 30058032›Full record

Observational studyJournal of gastrointestinal cancer2019

Vitamin D Levels in Patients with Colorectal Cancer Before and After Treatment Initiation.

Marissa B Savoie, Alan Paciorek, Li Zhang, Erin L Van Blarigan, Nilli Sommovilla, Donald Abrams, Chloe E Atreya, Emily K Bergsland, Hueylan Chern, Robin K Kelley and 6 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of gastrointestinal cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Serum and Salivary Levels of Phosphate in Gastric and Colorectal Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2024
    Article
  7. Article
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  11. Article
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  13. Review
  14. Nutrients · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Marissa B SavoieUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Alan PaciorekUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Li ZhangUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Erin L Van BlariganUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Nilli SommovillaUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Donald AbramsUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Chloe E AtreyaUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Emily K BergslandUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Hueylan ChernUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Robin K KelleyUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Andrew KoUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Angela LaffanUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Ankit SarinUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Madhulika G VarmaUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Alan P VenookUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Katherine Van LoonUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA. katherine.vanloon@ucsf.edu.
UCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of California, San Francisco · US

Funding

Diet After Colorectal Cancer : Observational Studies to Behavioral InterventionsK07CA197077 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAN BLARIGAN, ERIN LYNN · 2016 to 2020
$885k
Targeting of Aberrant Signaling in Patient-Derived Colorectal Cancer ModelsK08CA175153 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ATREYA, CHLOE E. · 2013 to 2017
$867k
NCI NIH HHS K07 CA197077NCI NIH HHS K08 CA175153
6 · The paper itself

Abstract

purposeWe aimed to described 25-hydroxyvitamin D [25(OH)D] levels in newly diagnosed colorectal cancer (CRC) patients and to re-evaluate levels after chemotherapy.

methodsPermanent residents of the San Francisco Bay Area with a new CRC diagnosis of any stage were recruited prior to any non-surgical therapy. Serum 25(OH)D levels were measured at time of diagnosis and 6-month follow-up. Supplement use was not restricted. The primary endpoint was the frequency of vitamin D deficiency in patients with newly diagnosed CRC of all stages. The Kruskal-Wallis and Spearman correlation tests were used to evaluate associations of patient characteristics with 25(OH)D levels.

resultsMedian 25(OH)D level at baseline was 27.0 ng/mL (range 7.2, 59.0); 65% of patients had insufficient levels (25(OH)D < 30 ng/mL) (n = 94). Race, disease stage, multivitamin use, vitamin D supplementation, and county of residence were associated with baseline 25(OH)D levels (P < 0.05). The median change in 25(OH)D from baseline to 6 months was - 0.7 ng/mL [- 19.4, 51.7] for patients treated with chemotherapy (n = 58) and 1.6 ng/mL [- 6.4, 33.2] for patients who did not receive chemotherapy (n = 19) (P = 0.26). For patients who received vitamin D supplementation during chemotherapy, the median 25(OH)D change was 8.3 ng/mL [- 7.6, 51.7] versus - 1.6 [- 19.4, 24.3] for chemotherapy patients who did not take vitamin D supplements (P = 0.02).

conclusionAmong patients with a new diagnosis of CRC, most patients were found to have 25(OH)D levels consistent with either deficiency or insufficiency. In the subset of patients who received chemotherapy and took a vitamin D supplement, serum 25(OH)D levels increased, suggesting that vitamin D repletion is a feasible intervention during chemotherapy.

Indexed as

AdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsColorectal NeoplasmsDietary SupplementsFeasibility StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRisk FactorsVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin DVitaminsChemotherapyColorectal cancerGeographic variationSupplementationVitamin D

Identifiers

PMID30058032
PMCPMC6650370
OpenAlexW2885321600

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.