Evidence map›Paper›PMID 30061107›Full record

ReviewThe Journal of cell biology2018

Transcriptional regulation of cell shape during organ morphogenesis.

Aravind Sivakumar, Natasza A Kurpios

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. The critical role of cardiolipin in metazoan differentiation, development, and maturation.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aravind SivakumarDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY.ORCID 0000-0002-8586-6924
Natasza A KurpiosDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY natasza.kurpios@cornell.edu.ORCID 0000-0002-1251-7395
Cornell University · US

Funding

Mechanisms underlying form and function of the contractile gut lymphaticsR01DK092776 · NIDDK · CORNELL UNIVERSITY · PI Natasza A Kurpios · 2012 to 2026
$5.6M
Gut-specific lymphatic patterns and progenitor heterogeneity during intestinal health and diseaseR01DK107634 · NIDDK · CORNELL UNIVERSITY · PI KURPIOS, NATASZA A · 2017 to 2021
$2.0M
NIDDK NIH HHS R01 DK092776NIDDK NIH HHS R01 DK107634
6 · The paper itself

Abstract

The emerging field of transcriptional regulation of cell shape changes aims to address the critical question of how gene expression programs produce a change in cell shape. Together with cell growth, division, and death, changes in cell shape are essential for organ morphogenesis. Whereas most studies of cell shape focus on posttranslational events involved in protein organization and distribution, cell shape changes can be genetically programmed. This review highlights the essential role of transcriptional regulation of cell shape during morphogenesis of the heart, lungs, gastrointestinal tract, and kidneys. We emphasize the evolutionary conservation of these processes across different model organisms and discuss perspectives on open questions and research avenues that may provide mechanistic insights toward understanding birth defects.

Indexed as

AnimalsCell ShapeCongenital AbnormalitiesGastrointestinal TractGene Expression Regulation, DevelopmentalHeartHumansKidneyLungOrganogenesisTranscription, Genetic

Identifiers

PMID30061107
PMCPMC6122985
OpenAlexW2886838981

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.