ArticleInternational journal of molecular sciences2018
Developmental Exposure to Atrazine Impairs Spatial Memory and Downregulates the Hippocampal D1 Dopamine Receptor and cAMP-Dependent Signaling Pathway in Rats.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Atrazine alters kisspeptin signaling and downstream neuroendocrine regulation following embryonic exposure in zebrafish.Toxicology · 2026Article
- Developmental neurotoxicity of atrazine: decreased synaptic spine density and miRNA-driven GluN2A downregulation in primary hippocampal neurons.Archives of toxicology · 2026Article
- Targeting Cardiotoxicity Induced by Environmental Toxins: The Role of Natural Products.Cardiovascular toxicology · 2025Review
- Integrated Analysis of Neuroendocrine and Neurotransmission Pathways Following Developmental Atrazine Exposure in Zebrafish.International journal of molecular sciences · 2024Article
- Exploring the potential mechanism of atrazine-induced dopaminergic neurotoxicity based on integration strategy.Environmental health and preventive medicine · 2024Article
- Inhibition of Fatty Acid Amide Hydrolase (FAAH) Regulates NF-kb Pathways Reducing Bleomycin-Induced Chronic Lung Inflammation and Pulmonary Fibrosis.International journal of molecular sciences · 2023Article
- Atrazine Toxicity: The Possible Role of Natural Products for Effective Treatment.Plants (Basel, Switzerland) · 2023Review
- Chronic Exposure to Endocrine Disruptor Vinclozolin Leads to Lung Damage via Nrf2-Nf-kb Pathway Alterations.International journal of molecular sciences · 2022Article
- Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory.Experimental animals · 2022Review
- Toxic Exposure to Endocrine Disruptors Worsens Parkinson's Disease Progression through NRF2/HO-1 Alteration.Biomedicines · 2022Article
- Histopathological, Immunohistochemical, And Molecular Alterations In Brain Tissue And Submandibular Salivary Gland Of Atrazine-Induced Toxicity In Male Rats.Environmental science and pollution research international · 2022Article
- Outcome of the first survey of atrazine in drinking water from Ijebu-North, South-West, Nigeria: Human health risk and neurotoxicological implications.Toxicology reports · 2022Article
- Chronic atrazine exposure increases the expression of genes associated with GABAergic and glutamatergic systems in the brain of male albino rat.Frontiers in toxicology · 2022Article
- Review
- Atrazine Inhalation Causes Neuroinflammation, Apoptosis and Accelerating Brain Aging.International journal of molecular sciences · 2021Article
- Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring.PloS one · 2020Article
- The Effects of Maternal Atrazine Exposure and Swimming Training on Spatial Learning Memory and Hippocampal Morphology in Offspring Male Rats via PSD95/NR2B Signaling Pathway.Cellular and molecular neurobiology · 2019Article
- HDAC-selective Inhibitor Cay10603 Has Single Anti-tumour Effect in Burkitt's Lymphoma Cells by Impeding the Cell Cycle.Current medical science · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atrazine (ATR) is a widely used herbicide that has been implicated as a neurotoxicant. Recent experimental evidence has implicated that ATR exposure also appears to have adverse effects on the hippocampus, which is a critical region for learning and memory. The aim of the present study was to investigate the effects of ATR toxicity on the hippocampus of developing rats. Postnatal day (PND) 28 male Sprague⁻Dawley (SD) rats received ATR by oral gavage at 10 or 100 mg/kg bodyweight (BW) for 30 consecutive days and were sacrificed at PND 90. Behavioral test results indicated that spatial learning and memory were affected by ATR treatment. Electron microscopy analysis showed that the ultrastructures of the hippocampus were altered in the ATR-treated groups, as compared to the control group. Additionally, ATR treatment impacted dopamine and D1 dopamine receptor (D1DR) contents through different mechanisms. Reduced mRNA and protein expression levels of factors involved in the cAMP-dependent signaling pathway were also detected. These results indicate that the developmental exposure of rats to ATR can damage the hippocampus and spatial memory, which might be related to the downregulation of expression levels of the D1DR and its downstream signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.