Evidence map›Paper›PMID 30083020›Full record

ArticleActa histochemica et cytochemica2018

Biochemical and Morphological Characterization of a Guanine Nucleotide Exchange Factor ARHGEF9 in Mouse Tissues.

Kyoko Ibaraki, Makoto Mizuno, Hitomi Aoki, Ayumi Niwa, Ikuko Iwamoto, Akira Hara, Hidenori Tabata, Hidenori Ito, Koh-Ichi Nagata

Open access · diamondAbstract read
In one paragraph

Article in Acta histochemica et cytochemica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. The influences of ARHGEF9 on myoblasts migration and differentiation.Journal of muscle research and cell motility · 2025
    Article
  2. Association analysis of polymorphisms inFrontiers in genetics · 2024
    Article
  3. Molecular Changes in the Brain of the WinteringInternational journal of molecular sciences · 2023
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kyoko IbarakiDepartment of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Aichi 480-0392, Japan.
Makoto MizunoDepartment of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Aichi 480-0392, Japan.
Hitomi AokiDepartment of Tissue and Organ Development, Gifu University Graduate School of Medicine, Gifu, Japan.
Ayumi NiwaDepartment of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.
Ikuko IwamotoDepartment of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Aichi 480-0392, Japan.
Akira HaraDepartment of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.
Hidenori TabataDepartment of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Aichi 480-0392, Japan.
Hidenori ItoDepartment of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Aichi 480-0392, Japan.
Koh-Ichi NagataDepartment of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Aichi 480-0392, Japan.
Aichi Human Service Center · JPGifu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ARHGEF9, also known as Collybistin, a guanine nucleotide exchange factor for Rho family GTPases, is thought to play an essential role in the mammalian brain. In this study, we prepared a specific polyclonal antibody against ARHGEF9, anti-ARHGEF9, and carried out expression analyses with mouse tissues especially brain. Western blotting analyses demonstrated tissue-dependent expression profiles of ARHGEF9 in the young adult mouse, and strongly suggested a role during brain development. Immunohistochemical analyses revealed developmental stage-dependent expression profiles of ARHGEF9 in cerebral cortex, hippocampus and cerebellum. ARHGEF9 exhibited partial localization at dendritic spines in cultured hippocampal neurons. From the obtained results, anti-ARHGEF9 was found to be a useful tool for biochemical and cell biological analyses of ARHGEF9.

Indexed as

antibodyARHGEF9cerebral cortexguanine nucleotide exchange factor (GEF)neuron

Identifiers

PMID30083020
PMCPMC6066644
OpenAlexW2809272508

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.