ReviewCurrent opinion in psychology2019
Non-coding genetic variation shaping mental health.
Review in Current opinion in psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- The cost of language: functionally over-dominant language circuits in the human brain may limit cognitive abilities and non-verbal executive functions.Frontiers in human neuroscience · 2025Article
- Predicting anxiety-related personality traits by means of serotonergic VNTR variants STin2 and 5-HTTLPR.Journal of mood and anxiety disorders · 2023Article
- Implementing Core Genes and an Omnigenic Model for Behaviour Traits Prediction in Genomics.Genes · 2023Review
- Precision medicine in mood disorders.PCN reports : psychiatry and clinical neurosciences · 2022Review
- Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.Nature human behaviour · 2021Article
- Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses.Genome medicine · 2021Article
- Structure analysis of deleterious nsSNPs in human PALB2 protein for functional inference.Bioinformation · 2021Article
- The social nature of mitochondria: Implications for human health.Neuroscience and biobehavioral reviews · 2021Review
- Neighborhood Environment and DNA Methylation: Implications for Cardiovascular Disease Risk.Journal of urban health : bulletin of the New York Academy of Medicine · 2019Review
- Treating the "E" in "G × E": Trauma-Informed Approaches and Psychological Therapy Interventions in Psychosis.Frontiers in psychiatry · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Over 98% of our genome is non-coding and is now recognised to have a major role in orchestrating the tissue specific and stimulus inducible gene expression pattern which underpins our wellbeing and mental health. The non-coding genome responds functionally to our environment at all levels, encompassing the span from psychological to physiological challenge. The gene expression pattern, termed the transcriptome, ultimately gives us our neurochemistry. Therefore a major modulator of mental wellbeing is how our genes are regulated in response to life experiences. Superimposed on the aforementioned non-coding DNA framework is a vast body of genetic variation in the elements that control response to challenges. These differences, termed polymorphisms, allow for a differential response from a specific DNA element to the same challenge thus potentially allowing 'individuality' in the modulation of our transcriptome. This review will focus on a fundamental mechanism defining our psychological and psychiatric wellbeing, namely how genetic variation can be correlated with differential gene expression in response to specific challenges, thus resulting in altered neurochemistry which consequently may shape behaviour.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.