Evidence map›Paper›PMID 30100615›Full record

ArticleThe pharmacogenomics journal2019

An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C.

Nyarai Desiree Soko, Emile Chimusa, Collen Masimirembwa, Collet Dandara

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In one paragraph

Article in The pharmacogenomics journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Nyarai Desiree SokoDivision of Human Genetic, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Emile ChimusaDivision of Human Genetic, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-8846-2047
Collen MasimirembwaAfrican Institute of Biomedical Science and Technology (AiBST), Wilkins Hospital, Corner Rekai Tangwena and Josiah Tongogara Ave, Harare, Zimbabwe.
Collet DandaraDivision of Human Genetic, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. collet.dandara@uct.ac.za.ORCID http://orcid.org/0000-0002-5925-4895
University of Cape Town · ZAAfrican Institute of Biomedical Science and Technology · ZW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies in Caucasian and Asian populations consistently associated interindividual and interethnic variability in rosuvastatin pharmacokinetics to the polymorphisms SLCO1B1 c.521T>C (rs4149056 p. Val174Ala) and ABCG2 c.421C>A (rs2231142, p. Gln141Lys). To investigate the pharmacogenetics of rosuvastatin in African populations, we first screened 785 individuals from nine ethnic African populations for the SLCO1B1 c.521C and ABCG2 c.421CA variants. This was followed by sequencing whole exomes from individuals of African Bantu descent, who participated in a 20 mg rosuvastatin pharmacokinetic trial in Harare Zimbabwe. Frequencies of SLCO1B1 c.521C ranged from 0.0% (San) to 7.0% (Maasai), while ABCG2 c.421A ranged from 0.0% (Shona) to 5.0% (Kikuyu). Variants showing significant association with rosuvastatin exposure were identified in SLCO1B1, ABCC2, SLC10A2, ABCB11, AHR, HNF4A, RXRA and FOXA3, and appear to be African specific. Interindividual differences in the pharmacokinetics of rosuvastatin in this African cohort cannot be explained by the polymorphisms SLCO1B1 c.521T>C and ABCG2 c.421C>A, but appear driven by a different set of variants.

Indexed as

Asian PeopleATP Binding Cassette Transporter, Subfamily G, Member 2Black PeopleExomeGenotypeHumansLiver-Specific Organic Anion Transporter 1Multidrug Resistance-Associated Protein 2Neoplasm ProteinsPharmacogeneticsPolymorphism, Single NucleotideRosuvastatin CalciumWhite PeopleZimbabweABCC2 protein, humanABCG2 protein, humanATP Binding Cassette Transporter, Subfamily G, Member 2Liver-Specific Organic Anion Transporter 1Multidrug Resistance-Associated Protein 2Neoplasm ProteinsRosuvastatin CalciumSLCO1B1 protein, human

Identifiers

PMID30100615
OpenAlexW2887501109

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.