Evidence map›Paper›PMID 30101294›Full record

ReviewNutrition reviews2018

Progress and perspectives in plant sterol and plant stanol research.

Peter J H Jones, Maryam Shamloo, Dylan S MacKay, Todd C Rideout, Semone B Myrie, Jogchum Plat, Jean-Baptiste Roullet, David J Baer, Kara L Calkins, Harry R Davis and 15 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Effect ofHeliyon · 2024
    Article
  9. Phytosterols: Potential Therapeutic Effects and Challenges in Food Industry.Advances in experimental medicine and biology · 2024
    Article
  10. Implication of Oxysterols and Phytosterols in Aging and Human Diseases.Advances in experimental medicine and biology · 2024
    Review
  11. β-Sitosterol Alleviates Neuropathic Pain by Affect Microglia Polarization through Inhibiting TLR4/NF-κB Signaling Pathway.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023
    Article
  12. Review
  13. Identification and Functional Characterization ofInternational journal of molecular sciences · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Peter J H JonesRichardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada.
Maryam ShamlooDepartment of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Dylan S MacKayGeorge and Fay Yee Centre for Healthcare Innovation, University of Manitoba, Winnipeg, Manitoba, Canada.
Todd C RideoutDepartment of Exercise and Nutrition Sciences, University of Buffalo, Buffalo, New York, USA.
Semone B MyrieRichardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada.
Jogchum PlatDepartment of Human Biology, Maastricht University, Maastricht, the Netherlands.
Jean-Baptiste RoulletDivision of Metabolism, Child Development and Rehabilitation Center-Portland, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA.
David J BaerUS Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, Maryland, USA.
Kara L CalkinsDepartment of Pediatrics, Division of Neonatology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA; and the UCLA Mattel's Children's Hospital, Los Angeles, California, USA.
Harry R DavisCVPath Institute, Inc, Gaithersburg, Maryland, USA.
P Barton DuellKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Henry GinsbergInstitute of Human Nutrition, Columbia University Irving Medical Center, New York, New York, USA.
Helena GyllingUniversity of Helsinki and the Helsinki University Central Hospital, Helsinki, Finland.
David JenkinsDepartment of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada; and the Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.
Dieter LütjohannInstitute for Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany.
Mohammad MoghadasianDepartment of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Robert A MoreauEastern Regional Research Center, US Department of Agriculture, Agricultural Research Service, Wyndmoor, Pennsylvania, USA.
David MyminDepartment of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Richard E OstlundDivision of Endocrinology, Metabolism and Lipid Research, Washington University, St Louis, USA.
Rouyanne T RasUnilever Research & Development Vlaardingen, Vlaardingen, the Netherlands.
Javier Ochoa ReparazDepartment of Biology, Eastern Washington University, Cheney, Washington, USA.
Elke A TrautweinUnilever Research & Development Vlaardingen, Vlaardingen, the Netherlands.
Stephen TurleyUT Southwestern Medical Center, Dallas, Texas, USA.
Tim VanmierloDepartment of Immunology and Biochemistry, Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
Oliver WeingärtnerKlinik für Innere Medizin I, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena, Germany; Abteilung für Kardiologie, Klinikum Oldenburg, European Medical School Oldenburg-Groningen, Oldenburg, Germany.

Funding

Institutional Career Development CoreKL2TR001882 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$1.0M
NCATS NIH HHS KL2 TR000122NCATS NIH HHS KL2 TR001882NCCIH NIH HHS K01 AT007826NCCIH NIH HHS R13 AT009270
6 · The paper itself

Abstract

Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.

Indexed as

Anticholesteremic AgentsCanadaCardiovascular DiseasesCholesterolCholesterol, LDLCongresses as TopicDietHumansHypercholesterolemiaIntestinal DiseasesLipid Metabolism, Inborn ErrorsPhytosterolsAnticholesteremic AgentsCholesterolCholesterol, LDLPhytosterols

Identifiers

PMID30101294
PMCPMC6130982

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.