ReviewCurrent pediatric reviews2018
Preterm Birth: Long Term Cardiovascular and Renal Consequences.
Review in Current pediatric reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 5 syntheses or guidelines pooled it, 186 citations in OpenAlex.
- Kidney health outcomes in children born very prematurely compared to full-term counterparts: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- Impact of preterm birth on muscle mass and function: a systematic review and meta-analysis.European journal of pediatrics · 2024Pooled it
- Pooled it
- The association between late preterm birth and cardiometabolic conditions across the life course: A systematic review and meta-analysis.Paediatric and perinatal epidemiology · 2022Pooled it
- The Long-Term Effect of Preterm Birth on Renal Function: A Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Group vs traditional prenatal care for improving racial equity in preterm birth and low birthweight: the Centering and Racial Disparities randomized clinical trial study.American journal of obstetrics and gynecology · 2022Trial
- Hypertensive disorders of pregnancy and offspring's kidney health.Pediatric nephrology (Berlin, Germany) · 2026Article
- Relationship between serum lipids/adipokines and obesity/hypertension in very-preterm infants during early childhood and preadolescence.Pediatric research · 2026Article
- Early postnatal nutrition and renal consequences in preterm infants.Pediatric research · 2026Review
- "Actionable" risk for preterm birth: patterns and prediction in California singleton births 2016-2020.BMC pregnancy and childbirth · 2026Article
- Association between impaired renal function based on decline in serum creatinine level and brain injury in neonates with hypoxic-ischemic encephalopathy.Clinical and experimental pediatrics · 2026Article
- Neighborhood socioeconomic disadvantage and early overweight of very preterm-born children: a cohort study in France.Pediatric research · 2026Article
- Tumor necrosis factor alpha inhibition improves fetal growth in a rat model of preeclampsia.Placenta · 2026Article
- Angiogenic Biomarkers and Neonatal Outcomes in Suspected Preeclampsia: Retrospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- The Link Between Preterm Birth and Long-Term Renal Consequences: Current Knowledge and Emerging Therapeutic Targets.Biomedicines · 2026Review
- Administration of Sodium Bicarbonate in Critically Ill Newborns: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2026Review
- Cardiac autonomic function in adults born preterm with very low birth weight in mid-adulthood-A two-country birth cohort study.Physiological reports · 2025Article
- Preterm Birth and Risk of Health Service Use, Morbidity, and Medication Needs at 5 Years.JAMA pediatrics · 2025Article
- Vaginal Deliveries Were as Safe as Cesarean Sections for the Long-Term Cardiovascular Health of Preterm Twins.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Maternal serum concentrations of vitamin D in pregnancy and preterm birth: a case-control study in Southern Sweden.European journal of nutrition · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular and chronic kidney diseases are a part of noncommunicable chronic diseases, the leading causes of premature death worldwide. They are recognized as having early origins through altered developmental programming, due to adverse environmental conditions during development. Preterm birth is such an adverse factor. Rates of preterm birth increased in the last decades, however, with the improvement in perinatal and neonatal care, a growing number of preterm born subjects has now entered adulthood. Clinical and experimental evidence suggests that preterm birth is associated with impaired or arrested structural or functional development of key organs/systems making preterm infants vulnerable to cardiovascular and chronic renal diseases at adulthood. This review analyzes the evidence of such cardiovascular and renal changes, the role of perinatal and neonatal factors such as antenatal steroids and potential pathogenic mechanisms, including developmental programming and epigenetic alterations.
conclusionPreterm born subjects are exposed to a significantly increased risk for altered cardiovascular and renal functions at young adulthood. Adequate, specific follow-up measures remain to be determined. While antenatal steroids have considerably improved preterm birth outcomes, repeated therapy should be considered with caution, as antenatal steroids induce long-term cardiovascular and metabolic alterations in animals' models and their involvement in the accelerated cellular senescence observed in human studies cannot be excluded.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.