ArticlePlant biology (Stuttgart, Germany)2019
The Myo-inositol pathway does not contribute to ascorbic acid synthesis.
Article in Plant biology (Stuttgart, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Overexpression ofInternational journal of molecular sciences · 2025Article
- Origin and evolution of signaling pathways responsible for ascorbic acid synthesis and catabolism during plant terrestrialization.Horticulture research · 2025Article
- Transcriptome Analysis Reveals Mechanisms of Stripe Rust Response in Wheat Cultivar Anmai1350.International journal of molecular sciences · 2025Article
- Integrated proteome and metabolome analysis of the penultimate internodes revealing remobilization efficiency in contrasting barley genotypes under water stress.Scientific reports · 2024Article
- Chloroplastic ascorbate modifies plant metabolism and may act as a metabolite signal regardless of oxidative stress.Plant physiology · 2024Article
- Genome and Transcriptome Analyses of Genes Involved in Ascorbate Biosynthesis in Pepper Indicate Key Genes Related to Fruit Development, Stresses, and Phytohormone Exposures.Plants (Basel, Switzerland) · 2023Article
- ETHYLENE-INSENSITIVE 3-LIKE 2 regulates β-carotene and ascorbic acid accumulation in tomatoes during ripening.Plant physiology · 2023Article
- QTL analysis for ascorbic acid content in strawberry fruit reveals a complex genetic architecture and association with GDP-L-galactose phosphorylase.Horticulture research · 2023Article
- Suppression of theLife (Basel, Switzerland) · 2023Article
- Transcriptome comparison analyses in UV-B induced AsA accumulation of Lactuca sativa L.BMC genomics · 2023Article
- The Functions of Chloroplastic Ascorbate in Vascular Plants and Algae.International journal of molecular sciences · 2023Review
- AHL-Priming Protein 1 mediates N-3-oxo-tetradecanoyl-homoserine lactone priming in Arabidopsis.BMC biology · 2022Article
- Potential of engineering the myo-inositol oxidation pathway to increase stress resilience in plants.Molecular biology reports · 2022Review
- Metabolic engineering in food crops to enhance ascorbic acid production: crop biofortification perspectives for human health.Physiology and molecular biology of plants : an international journal of functional plant biology · 2022Review
- Ascorbate synthesis as an alternative electron source for mitochondrial respiration: Possible implications for the plant performance.Frontiers in plant science · 2022Review
- Exogenous brassinolide improves the antioxidant capacity ofFrontiers in plant science · 2022Article
- Genome-Wide Analysis of Ascorbic Acid Metabolism Related Genes inFrontiers in plant science · 2022Article
- Transcriptomic Changes in Internode Explants of Stinging Nettle during Callogenesis.International journal of molecular sciences · 2021Article
- A Transcriptional Analysis of the Genes Involved in the Ascorbic Acid Pathways Based on a Comparison of the Juice and Leaves of Navel and Anthocyanin-Rich Sweet Orange Varieties.Plants (Basel, Switzerland) · 2021Article
- Regulation of Vitamin C Accumulation for Improved Tomato Fruit Quality and Alleviation of Abiotic Stress.Genes · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Ascorbic acid (AsA) biosynthesis in plants predominantly occurs via a pathway with d-mannose and l-galactose as intermediates. One alternative pathway for AsA synthesis, which is similar to the biosynthesis route in mammals, is controversially discussed for plants. Here, myo-inositol is cleaved to glucuronic acid and then converted via l-gulonate to AsA. In contrast to animals, plants have an effective recycling pathway for glucuronic acid, being a competitor for the metabolic rate. Recycling involves a phosphorylation at C1 by the enzyme glucuronokinase. Two previously described T-DNA insertion lines in the gene coding for glucuronokinase1 show wild type-like expression levels of the mRNA in our experiments and do not accumulate glucuronic acid in labelling experiments disproving that these lines are true knockouts. As suitable T-DNA insertion lines were not available, we generated frameshift mutations in the major expressed isoform glucuronokinase1 (At3g01640) to potentially redirect metabolites to AsA. However, radiotracer experiments with
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.