ArticleJournal of Alzheimer's disease : JAD2018
Depressive Symptoms Are Associated with Cognitive Function in the Elderly with Type 2 Diabetes.
Article in Journal of Alzheimer's disease : JAD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Impact of functional level on cognitive function in adults aged 45 and older than 45 years in the Korean Longitudinal Study of Aging.Australasian journal on ageing · 2025Article
- Social Support, Coping Strategies, Depression, Anxiety, and Cognitive Function Among People With Type 2 Diabetes Mellitus: A Path Analysis.Psychiatry investigation · 2024Article
- Exploring the Role of Social Factors in Cognitive Frailty among South Korean Older Adults.Healthcare (Basel, Switzerland) · 2024Article
- Depressive symptoms mediate the relationship between diabetes and cognitive performance in a community-based sample of older adults.Journal of diabetes and its complications · 2022Article
- Specific Dimensions of Depression Have Different Associations With Cognitive Decline in Older Adults With Type 2 Diabetes.Diabetes care · 2021Article
- Diagnosis of TCM symptoms and analysis of risk factors of mild cognitive impairment in patients with type 2 diabetes mellitus.American journal of translational research · 2021Article
- Increase in Number of Depression Symptoms Over Time is Related to Worse Cognitive Outcomes in Older Adults With Type 2 Diabetes.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Article
- Executive Function and Diabetes: A Clinical Neuropsychology Perspective.Frontiers in psychology · 2020Review
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Authors and funding
11 authors.
Funding
Abstract
backgroundType 2 diabetes (T2D) is a metabolic condition associated with poor clinical and cognitive outcomes including vascular disease, depressive symptoms, cognitive impairment, and dementia. In the general elderly population, depression has been consistently identified as a risk factor for cognitive impairment/decline. However, the association between depression and cognitive function in T2D has been understudied.
objectiveWe investigated the association between depression and cognitive function in a large sample of cognitively normal elderly with T2D.
methodsIn this cross-sectional study, we examined 738 participants, aged 65-88 years old, enrolled in the Israel Diabetes and Cognitive Decline study. For each cognitive domain (Episodic Memory, Executive Function, Attention/Working Memory, Language/Semantic Categorization) and Overall Cognition, multiple linear regressions assessed its association with depression (score greater than 5 on the 15-item version of the Geriatric Depression Scale [GDS]), adjusting for age, sex, and education.
resultsDepression (n = 66, 8.9%) was associated with worse performance on tasks of Executive Function (p = 0.004), Language/Semantic Categorization (p < 0.001), and Overall Cognition (p < 0.002), but not Episodic Memory (p = 0.643) or Attention/Working Memory (p = 0.488). Secondary analyses using GDS as a continuous variable did not substantially change the results. Adjusting also for a history of antidepressant medication use slightly weakened the findings.
conclusionSignificant associations of depression with several cognitive domains and Overall Cognition even in cognitively normal elderly with T2D, suggest that depression may have a role in impaired cognitive function in T2D, which may be attenuated by antidepressants.
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