Evidence map›Paper›PMID 30105065›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2018

Neuronal Specificity of Acupuncture in Alzheimer's Disease and Mild Cognitive Impairment Patients: A Functional MRI Study.

Yi Shan, Jing-Juan Wang, Zhi-Qun Wang, Zhi-Lian Zhao, Mo Zhang, Jian-Yang Xu, Ying Han, Kun-Cheng Li, Jie Lu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yi ShanDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-2646-8835
Jing-Juan WangDepartment of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Zhi-Qun WangDepartment of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Zhi-Lian ZhaoDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Mo ZhangDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jian-Yang XuDepartment of Integrated TCM and Western Medicine, General Hospital of Chinese People's Armed Police Forces, Beijing, China.
Ying HanDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Kun-Cheng LiDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jie LuDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-0425-3921
Capital Medical University · CNBeijing University of Chinese Medicine · CNShenzhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although acupuncture is considered to be effective and safe for Alzheimer's disease (AD) and mild cognitive impairment (MCI), the mechanism underlying its therapeutic effect is still unknown. Most studies clarifying the neuronal pathway produced by acupuncture were still applied to healthy subjects with limited single acupuncture point stimulation, which was inconsistency with clinical practice. Thus, in our present study, we investigate the differences between brain activity changes in AD and MCI patients caused by multi-acupuncture point Siguan (four gates), in order to provide visualized evidence for neuronal specificity of clinical acupuncture. Forty-nine subjects were recruited, including 21 AD patients, 14 MCI patients, and 14 healthy controls (HC). AD and MCI patients were randomly divided into two groups, respectively: real acupuncture point group (14 AD and 8 MCI) and sham acupuncture point group (7 AD and 6 MCI). We adopted a 16-minute, single-block, experimental design for acquiring functional MRI images. We found, in AD and MCI patients, Siguan (four gates) elicited extensive activations and deactivations in cognitive-related areas, visual-related areas, the sensorimotor-related area, basal ganglia, and cerebellum. Compared with HC, AD and MCI patients showed similar activations in cognitive-related brain areas (inferior frontal gyrus, supramarginal gyrus, and rolandic operculum) as well as deactivations in cognitive-related areas, visual-related areas, basal ganglia, and cerebellum, which were not found in HC. Compared with sham acupuncture points, real acupuncture points produced more specific brain changes with both activated and deactivated brain activities in AD and MCI. The preliminary results in our study verified the objective evidence for neuronal specificity of acupuncture in AD and MCI patients.

Identifiers

PMID30105065
PMCPMC6076908
OpenAlexW2883852853

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.