Evidence map›Paper›PMID 30105479›Full record

SynthesisCurrent diabetes reports2018

Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review.

Zeinab Nazarian-Samani, Robert D E Sewell, Zahra Lorigooini, Mahmoud Rafieian-Kopaei

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current diabetes reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 93 citations in OpenAlex.

  1. Pharmaceutics · 2026
    Review
  2. Effect ofLife (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. The Emerging Importance of Cirsimaritin in Type 2 Diabetes Treatment.International journal of molecular sciences · 2023
    Article
  7. Antioxidant, Cytotoxicity, Antimicrobial Activity, andBiochemistry research international · 2023
    Article
  8. Heliyon · 2022
    Article
  9. Review
  10. Oakmoss Exhibits Antihyperglycemic Activity in Streptozotocin-Induced Diabetic Rats.Cardiovascular & hematological disorders drug targets · 2022
    Article
  11. Review
  12. Activation of Insulin Signaling by Botanical Products.International journal of molecular sciences · 2021
    Review
  13. Efficient Separation of Phytochemicals fromMolecules (Basel, Switzerland) · 2021
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Zeinab Nazarian-SamaniBasic Science Department, Veterinary Medicine Faculty, Shahrekord University, Shahrekord, Iran.
Robert D E SewellCardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, Wales, CF10 3NB, UK.
Zahra LorigooiniMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Mahmoud Rafieian-KopaeiMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. rafieian@yahoo.com.
Shahrekord University of Medical Sciences · IRCardiff University · GBShahrekord University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis systematic review describes evidence concerning medicinal plants that, in addition to exerting hypoglycemic effects, decrease accompanying complications such as nephropathy, neuropathy, retinopathy, hypertension, and/or hyperlipidemia among individuals with diabetes mellitus (DM). RECENT

findingsStudies on the antidiabetic mechanisms of medicinal plants have shown that most of them produce hypoglycemic activity by stimulating insulin secretion, augmenting peroxisome proliferator-activated receptors (PPARs), inhibiting α-amylase or α-glucosidase, glucagon-like peptide-1 (GLP-1) secretion, advanced glycation end product (AGE) formation, free radical scavenging plus antioxidant activity (against reactive oxygen or nitrogen species (ROS/RNS)), up-regulating or elevating translocation of glucose transporter type 4 (GLUT-4), and preventing development of insulin resistance. Not only are medicinal plants effective in DM, but many of them also possess a variety of effects on other disease states, including the complications of DM. Such plants may be appropriate alternatives or adjuncts to available antidiabetic medications.

Indexed as

Diabetes ComplicationsDiabetes MellitusHumansHypoglycemic AgentsInsulin ResistancePeroxisome Proliferator-Activated ReceptorsPlants, MedicinalHypoglycemic AgentsPeroxisome Proliferator-Activated ReceptorsDiabetes mellitusMedicinal plantsNephropathyNeuropathy

Identifiers

PMID30105479
OpenAlexW2887204990

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.