ArticleCellular and molecular gastroenterology and hepatology2018
Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer.
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Article in Cellular and molecular gastroenterology and hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
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Who cites it
39 citing papers in PubMed, 63 citations in OpenAlex.
- Trial
- eQTL in diseased colon tissue identifies potential target genes associated with IBD.Nature communications · 2026Article
- Regulation and Function of Sox2 and CD44 Expression in the Stomach by Bone Morphogenetic Protein Signaling.Gastro hep advances · 2026Article
- Ulcerative colitis and colorectal cancer: Pathogenic insights and precision strategies for prevention and treatment.World journal of gastrointestinal oncology · 2025Review
- ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma.Cell reports. Medicine · 2025Article
- Epithelial-specific loss of Smad4 alleviates the fibrotic response in an acute colitis mouse model.Life science alliance · 2024Article
- Interaction of the tumor suppressor SMAD4 and WNT signaling in progression to oral squamous cell carcinoma.The Journal of pathology · 2024Article
- Single-cell RNA sequencing analysis of vestibular schwannoma reveals functionally distinct macrophage subsets.British journal of cancer · 2024Article
- Concordant B and T Cell Heterogeneity Inferred from the Multiomic Landscape of Peripheral Blood Mononuclear Cells in a Crohn's Disease Cohort.Journal of Crohn's & colitis · 2024Article
- Smad4 Deficiency in S100A4International journal of biological sciences · 2024Article
- CRISPR/Cas9: a powerful tool in colorectal cancer research.Journal of experimental & clinical cancer research : CR · 2023Review
- Innovative molecular subtypes of multiple signaling pathways in colon cancer and validation of FMOD as a prognostic-related marker.Journal of cancer research and clinical oncology · 2023Article
- Synthesis of Bis-Chalcones and Evaluation of Its Effect on Peroxide-Induced Cell Death and Lipopolysaccharide-Induced Cytokine Production.Molecules (Basel, Switzerland) · 2023Article
- Transforming Growth Factor Beta Promotes Inflammation and Tumorigenesis in Smad4-Deficient Intestinal Epithelium in a YAP-Dependent Manner.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Stem cell-derived intestinal organoids: a novel modality for IBD.Cell death discovery · 2023Review
- Ten Years of CRISPRing Cancers In Vitro.Cancers · 2022Review
- SMAD4 Suppresses Colitis-associated Carcinoma Through Inhibition of CCL20/CCR6-mediated Inflammation.Gastroenterology · 2022Article
- Patient-derived organoids for therapy personalization in inflammatory bowel diseases.World journal of gastroenterology · 2022Review
- From inflammatory bowel disease to colorectal cancer: what's the role of miRNAs?Cancer cell international · 2022Review
- Chemokines in progression, chemoresistance, diagnosis, and prognosis of colorectal cancer.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
24 authors at 3 institutions in 1 country.
Anna L MeansDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Tanner J FreemanDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Jing ZhuDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Luke G WoodburyDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Paula Marincola-SmithDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Chao WuDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Anne R MeyerDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Connie J WeaverDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Chandrasekhar PadmanabhanDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Hanbing AnDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Jinghuan ZiDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Bronson C WessingerDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Rupesh ChaturvediDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Tasia D BrownDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Natasha G DeaneDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Robert J CoffeyVanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Keith T WilsonVanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
J Joshua SmithDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Charles L SawyersDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
James R GoldenringDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Sergey V NovitskiyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
M Kay WashingtonVanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Chanjuan ShiVanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
R Daniel BeauchampDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Vanderbilt University Medical Center · USMemorial Sloan Kettering Cancer Center · USVA Tennessee Valley Healthcare System · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8MUnderstanding and Controlling p120 Dysfunction in CRCP50CA095103 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2002 to 2017
$33.6MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MIntegrated approach to study early and late events in colonic neoplasia: mouse to manR35CA197570 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2017 to 2026
$9.4MTRAINING PROGRAM IN CELLULAR, BIOCHEMICAL, &MOLECULAR ST32GM008554 · NIGMS · VANDERBILT UNIVERSITY · PI PATTON, JAMES G. · 1995 to 2020
$7.4MSurgical Oncology Training GrantT32CA106183 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI James Richard Goldenring · 2004 to 2026
$6.0MREGULATION OF GUT EPITHELIAL CELL PROLIFERATIONR01CA069457 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BEAUCHAMP, ROBERT DANIEL · 1995 to 2016
$4.4MImmunomodulatory effects of arginine supplementation in colitis and colon cancerR01AT004821 · NCCIH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 2008 to 2017
$4.0MMechanisms of Gastric Mucous Cell MetaplasiaR01DK071590 · NIDDK · VANDERBILT UNIVERSITY · PI GOLDENRING, JAMES RICHARD · 2008 to 2012
$2.2MRole of Adenosine in TGF-beta Effects in CancersR01CA200681 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NOVITSKIY, SERGEY V. · 2016 to 2020
$1.8MSmad4 promotes intestinal homeostasis through suppression of Wnt signalingF30CA165726 · NCI · VANDERBILT UNIVERSITY · PI FREEMAN, TANNER J. · 2012 to 2015
$144kBLRD VA I01 BX000930BLRD VA I01 BX001453Howard Hughes Medical InstituteNCCIH NIH HHS R01 AT004821NCI NIH HHS F30 CA165726NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA095103NCI NIH HHS R01 CA069457NCI NIH HHS R01 CA200681NCI NIH HHS R35 CA197570NCI NIH HHS T32 CA106183NIDDK NIH HHS F31 DK117592NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK071590NIGMS NIH HHS T32 GM008554
Abstract
Background & Aims: Chronic inflammation is a predisposing condition for colorectal cancer. Many studies to date have focused on proinflammatory signaling pathways in the colon. Understanding the mechanisms that suppress inflammation, particularly in epithelial cells, is critical for developing therapeutic interventions. Here, we explored the roles of transforming growth factor β (TGFβ) family signaling through SMAD4 in colonic epithelial cells. Methods: The Results: Dextran sodium sulfate treatment was sufficient to drive carcinogenesis in mice lacking colonic Conclusions: TGFβ suppresses the expression of proinflammatory genes in the colon epithelium, and loss of its downstream mediator, SMAD4, is sufficient to initiate inflammation-driven colon cancer. Transcript profiling: GSE100082.
Indexed as
AnimalsBone Morphogenetic Protein 2CarcinomaCell LineCell Line, TumorColitisColorectal NeoplasmsDextran SulfateHumansInflammationIntestinal MucosaMiceMice, Inbred C57BLMice, TransgenicSmad4 ProteinTransforming Growth Factor beta1Bmp2 protein, mouseBone Morphogenetic Protein 2Dextran SulfateSmad4 ProteinSmad4 protein, mouseTransforming Growth Factor beta1AOM, azoxymethaneAPC, adenomatous polyposis coliBMP, bone morphogenetic proteinCAC, colitis-associated carcinomaCCL20, Chemokine (C-C motif) ligand 20Colitis-Associated CarcinomaCRC, colorectal cancerCRISPR/Cas9, Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9DMEM, Dulbecco's modified Eagle mediumDSS, dextran sodium sulfateFBS, fetal bovine serumFDR, false discovery rateGFP, green fluorescent proteinHBSS, Hank's balanced salt solutionIBD, inflammatory bowel diseaseIL, interleukinIMCS4fl/fl, immortalized mouse colonoctye cell line with loxP-flanked Smad4 allelesIMCS4null, immortalized mouse colonocyte cell line with deletion of the Smad4 allelesLPS, lipopolysaccharidemRNA, messenger RNAPBS, phosphate-buffered salinePE, phycoerythrinR-SMAD, Receptor-SMADSFG, retroviral vectorsgRNA, single-guide RNASTAT3, signal transducer and activator of transcription 3TGFβTGFβ, transforming growth factor βTNF, tumor necrosis factorTumor Necrosis FactorUC, ulcerative colitisWNT, wingless-type mouse mammary tumor virus integration siteYAMC, young adult mouse colon epithelial cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.