Evidence map›Paper›PMID 30113882›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Stabilization of p27

Elizabeth A Whitcomb, Yien Che Tsai, Johnvesly Basappa, Ke Liu, Aurélie K Le Feuvre, Allan M Weissman, Allen Taylor

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Transcriptome sequencing (RNA-Seq) reveals non-coding pseudogene CDC27P9 role in cervical cancer.Apoptosis : an international journal on programmed cell death · 2026
    Article
  3. Proteostasis in aging-associated ocular disease.Molecular aspects of medicine · 2022
    Review
  4. Genes · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elizabeth A WhitcombLaboratory for Nutrition and Vision Research Jean Mayer-U.S. Department of Agriculture (JM-USDA) Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
Yien Che TsaiLaboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.
Johnvesly BasappaLaboratory for Nutrition and Vision Research Jean Mayer-U.S. Department of Agriculture (JM-USDA) Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
Ke LiuLaboratory for Nutrition and Vision Research Jean Mayer-U.S. Department of Agriculture (JM-USDA) Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
Aurélie K Le FeuvreLaboratory for Nutrition and Vision Research Jean Mayer-U.S. Department of Agriculture (JM-USDA) Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
Allan M WeissmanLaboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.
Allen TaylorLaboratory for Nutrition and Vision Research Jean Mayer-U.S. Department of Agriculture (JM-USDA) Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.
Tufts University · USJean Mayer Human Nutrition Research Center on Aging · USNational Cancer Institute · US

Funding

Enzymes and Substrates of the Ubiquitin Conjugating SystemZIABC010292 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WEISSMAN, ALLAN M · 2009 to 2024
$12.2M
Ubiquitin Function In Eye LensR01EY013250 · NEI · TUFTS UNIVERSITY BOSTON · PI TAYLOR, ALLEN · 2001 to 2012
$4.0M
Mechanistically linking AMD, glycemic index and protein homeostasisR01EY028559 · NEI · TUFTS UNIVERSITY BOSTON · PI TAYLOR, ALLEN · 2018 to 2022
$1.5M
Ubiquitin function in eye lensR01EY026979 · NEI · TUFTS UNIVERSITY BOSTON · PI TAYLOR, ALLEN · 2016 to 2018
$1.2M
Mechanistically linking AMD, glycemic index and protein homeostasisR01EY021212 · NEI · TUFTS UNIVERSITY BOSTON · PI TAYLOR, ALLEN · 2011 to 2013
$1.2M
NEI NIH HHS R01 EY013250NEI NIH HHS R01 EY021212NEI NIH HHS R01 EY026979NEI NIH HHS R01 EY028559
6 · The paper itself

Abstract

Ubiquitinylation drives many cellular processes by targeting proteins for proteasomal degradation. Ubiquitin conjugation enzymes promote ubiquitinylation and, thus, degradation of protein substrates. Ubiquitinylation is a well-known posttranslational modification controlling cell-cycle transitions and levels or/and activation levels of ubiquitin-conjugating enzymes change during development and cell cycle. Progression through the cell cycle is tightly controlled by CDK inhibitors such as p27

Indexed as

Cell CycleCatalysisCell LineCyclin-Dependent Kinase Inhibitor p27HumansLens, CrystallineProteolysisSubstrate SpecificityUbiquitinUbiquitinationUbiquitin-Conjugating EnzymesCyclin-Dependent Kinase Inhibitor p27UBE2L3 protein, humanUbiquitinUbiquitin-Conjugating EnzymesCDKIcell divisionproteasomeubiquitin-conjugating enzyme

Identifiers

PMID30113882
PMCPMC6355086
OpenAlexW2886049549

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.