Evidence map›Paper›PMID 30115811›Full record

ArticleAging2018

Remote ischemic conditioning: a promising therapeutic intervention for multi-organ protection.

Da Zhou, Jiayue Ding, Jingyuan Ya, Liqun Pan, Yuan Wang, Xunming Ji, Ran Meng

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06501222 (The Renal Protective Effects of Remote Ischemic Preconditioning in Patients With Chronic Kidney Disease), which is not on this map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06501222 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Renal Protective Effects of Remote Ischemic Preconditioning in Patients With Chronic Kidney Disease: Randomized, Parallel-controlled, proof-of Concept Trial

TypeinterventionalSponsorYuanjun YangRan2024 to 2027Enrolled114ConditionsChronic Kidney DiseasesArmsRemote ischemic conditioning
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  6. Lipoprotein(a), remote ischemic conditioning, and stroke recurrence in patients with symptomatic intracranial atherosclerotic stenosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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  9. Bioenergetics of the combat sports brain: Between risk and resilience.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Da Zhou *Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jiayue Ding *Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jingyuan YaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Liqun PanDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yuan WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xunming JiDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Ran MengDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite decades of formidable exploration, multi-organ ischemia-reperfusion injury (IRI) encountered, particularly amongst elderly patients with clinical scenarios, such as age-related arteriosclerotic vascular disease, heart surgery and organ transplantation, is still an unsettled conundrum that besets clinicians. Remote ischemic conditioning (RIC), delivered via transient, repetitive noninvasive IR interventions to distant organs or tissues, is regarded as an innovative approach against IRI. Based on the available evidence, RIC holds the potential of affording protection to multiple organs or tissues, which include not only the heart and brain, but also others that are likely susceptible to IRI, such as the kidney, lung, liver and skin. Neuronal and humoral signaling pathways appear to play requisite roles in the mechanisms of RIC-related beneficial effects, and these pathways also display inseparable interactions with each other. So far, several hurdles lying ahead of clinical translation that remain to be settled, such as establishment of biomarkers, modification of RIC regimen, and deep understanding of underlying minutiae through which RIC exerts its powerful function. As this approach has garnered an increasing interest, herein, we aim to encapsulate an overview of the basic concept and postulated protective mechanisms of RIC, highlight the main findings from proof-of-concept clinical studies in various clinical scenarios, and also to discuss potential obstacles that remain to be conquered. More well designed and comprehensive experimental work or clinical trials are warranted in future research to confirm whether RIC could be utilized as a non-invasive, inexpensive and efficient adjunct therapeutic intervention method for multi-organ protection.

Indexed as

AgedHumansIschemic PreconditioningOxygen ConsumptionReperfusion Injuryage-related arteriosclerotic vascular diseaseclinical translationischemia-reperfusion injurymulti-organ protectionremote ischemic conditioning

Identifiers

PMID30115811
PMCPMC6128414

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.