Evidence map›Paper›PMID 30116778›Full record

ArticleScience advances2018

A mouse model of 22q11.2 deletions: Molecular and behavioral signatures of Parkinson's disease and schizophrenia.

Akiko Sumitomo, Kouta Horike, Kazuko Hirai, Nancy Butcher, Erik Boot, Takeshi Sakurai, Frederick C Nucifora, Anne S Bassett, Akira Sawa, Toshifumi Tomoda

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Akiko SumitomoDepartment of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kouta HorikeDepartment of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kazuko HiraiDepartment of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Nancy ButcherClinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Erik BootDalglish Family 22q Clinic, University Health Network, Toronto General Research Institute, and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-0593-1539
Takeshi SakuraiDepartment of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Frederick C NuciforaDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Anne S BassettClinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Akira SawaDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Toshifumi TomodaDepartment of Research and Drug Discovery, Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kyoto University · JPCentre for Addiction and Mental Health · CAJohns Hopkins University · USUniversity Health Network · CA

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9M
WOUND MIGRATION FORCE MONITORINGP41RR001192 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI TROMBERG, BRUCE J. · 1985 to 2011
$14.2M
High throughput marker for cognitive deficit: cellular autofluorescenceR01MH107730 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2018 to 2022
$3.0M
DISC1-dependent defects in neural fate, corticogenesis and cognition in psychosisR01MH105660 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ISHIZUKA, KOKO, SAWA, AKIRA · 2014 to 2018
$2.8M
Oxidative stress and schizophrenia: combination of cell biology and brain imagingR01MH092443 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2015
$1.8M
3/5 International Consortium on Brain and Behavior in 22q11.2 Deletion SyndromeU01MH101723 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI BASSETT, ANNE S., CHOW, EVA W. C. · 2013 to 2016
$821k
NCRR NIH HHS P41 RR001192NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH092443NIMH NIH HHS R01 MH105660NIMH NIH HHS R01 MH107730NIMH NIH HHS U01 MH101723
6 · The paper itself

Abstract

Individuals with chromosome 22q11.2 deletions are at increased risk of developing psychiatric conditions, most notably, schizophrenia (SZ). Recently, clinical studies have also implicated these recurrent 22q11.2 deletions with the risk of early-onset Parkinson's disease (PD). Thus far, the multiple mouse models generated for 22q11.2 deletions have been studied primarily in the context of congenital cardiac, neurodevelopmental, and psychotic disorders. One of these is the

Indexed as

Behavior, AnimalDisease Models, AnimalSequence Deletionalpha-SynucleinAnimalsChromosomes, Human, Pair 22DiGeorge SyndromeHumansMaleMiceMice, Inbred C57BLMice, KnockoutParkinson DiseaseSchizophreniaalpha-Synuclein

Identifiers

PMID30116778
PMCPMC6093626
OpenAlexW2886135244

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.