Evidence map›Paper›PMID 30126238›Full record

ReviewViruses2018

The Diverse Roles of microRNAs at the Host⁻Virus Interface.

Annie Bernier, Selena M Sagan

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.

  1. The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021
    Pooled it
  2. Review
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  18. Analysis of miRNAs involved in mouse brain injury upon Coxsackievirus A6 infection.Frontiers in cellular and infection microbiology · 2024
    Article
  19. MiR-130c-5p targets the SHVVFrontiers in immunology · 2024
    Article
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Annie BernierDepartment of Microbiology & Immunology, McGill University, Montréal, QC H3G 1Y6, Canada. Annie.bernier@mail.mcgill.ca.
Selena M SaganDepartment of Microbiology & Immunology, McGill University, Montréal, QC H3G 1Y6, Canada. selena.sagan@mcgill.ca.ORCID 0000-0002-8484-3632
McGill University · CA

Funding

CIHR MOP-136915
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Through this activity, they are implicated in almost every cellular process investigated to date. Hence, it is not surprising that miRNAs play diverse roles in regulation of viral infections and antiviral responses. Diverse families of DNA and RNA viruses have been shown to take advantage of cellular miRNAs or produce virally encoded miRNAs that alter host or viral gene expression. MiRNA-mediated changes in gene expression have been demonstrated to modulate viral replication, antiviral immune responses, viral latency, and pathogenesis. Interestingly, viruses mediate both canonical and non-canonical interactions with miRNAs to downregulate specific targets or to promote viral genome stability, translation, and/or RNA accumulation. In this review, we focus on recent findings elucidating several key mechanisms employed by diverse virus families, with a focus on miRNAs at the host⁻virus interface during herpesvirus, polyomavirus, retroviruses, pestivirus, and hepacivirus infections.

Indexed as

Gene Expression Regulation, ViralGenome, ViralHepacivirusHerpesviridaeHumansImmune EvasionMicroRNAsNucleic Acid ConformationPestivirusPolyomavirusRetroviridaeRNA, ViralSignal TransductionVirus DiseasesVirus LatencyVirus ReplicationMicroRNAsRNA, ViralhepacivirusesHerpesvirusesimmune evasionlatencymicroRNAspestivirusespolyomavirusesretrovirusesviral RNA accumulation

Identifiers

PMID30126238
PMCPMC6116274
OpenAlexW2888657086

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.