Evidence map›Paper›PMID 30126412›Full record

ReviewReproductive biology and endocrinology : RB&E2018

A novel and compact review on the role of oxidative stress in female reproduction.

Jiayin Lu, Zixu Wang, Jing Cao, Yaoxing Chen, Yulan Dong

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reproductive biology and endocrinology : RB&E, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06261671 (Antioxidants-enriched Single-step vs Global Total Single-step Embryo Culture Media), which is not on this map. Cited by 239 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
239citing papers in PubMed, 6 pooled it
35.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06261671 narecruitingnot on this mapstarted 2024, after this paper: background citation

Antioxidants-enriched Single-step vs Global Total Single-step Embryo Culture Media: Effect on Blastocyst Euploidy Rates.

TypeinterventionalSponsorART Fertility Clinics LLCRan2024 to 2025Enrolled500ConditionsInfertility, In Vitro FertilizationArmsantioxidants-enriched culture medium (Gx)
3 · Its place in the literature

Who cites it

239 citing papers in PubMed, 6 syntheses or guidelines pooled it, 467 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effects of vitamin D supplementation on oxidative stress biomarkers of Iranian women with polycystic ovary syndrome: a meta-analysis study.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024
    Pooled it
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  7. Trial
  8. Article
  9. Review
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  11. Article
  12. Article
  13. Review
  14. iMeta · 2026
    Article
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  18. Lower Plasma Antioxidant Defense and Heat Shock Proteins Mark Intra-Amniotic Sludge Ultrasound Finding.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
    Article
  19. Article
  20. Review

179 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jiayin LuLaboratory of Neurobiology, College of Animal Medicine, China Agricultural University, Haidian, Beijing, 100193, People's Republic of China.
Zixu WangLaboratory of Neurobiology, College of Animal Medicine, China Agricultural University, Haidian, Beijing, 100193, People's Republic of China.
Jing CaoLaboratory of Neurobiology, College of Animal Medicine, China Agricultural University, Haidian, Beijing, 100193, People's Republic of China.
Yaoxing ChenLaboratory of Neurobiology, College of Animal Medicine, China Agricultural University, Haidian, Beijing, 100193, People's Republic of China. yxchen@cau.edu.cn.
Yulan DongLaboratory of Neurobiology, College of Animal Medicine, China Agricultural University, Haidian, Beijing, 100193, People's Republic of China. ylbcdong@cau.edu.cn.
China Agricultural University · CN

Funding

National Natural Science Foundation of Beijing 6172022National Natural Science Foundation of China 31572476,31272483, 31372332
6 · The paper itself

Abstract

In recent years, the study of oxidative stress (OS) has become increasingly popular. In particular, the role of OS on female fertility is very important and has been focused on closely. The occurrence of OS is due to the excessive production of reactive oxygen species (ROS). ROS are a double-edged sword; they not only play an important role as secondary messengers in many intracellular signaling cascades, but they also exert indispensable effects on pathological processes involving the female genital tract. ROS and antioxidants join in the regulation of reproductive processes in both animals and humans. Imbalances between pro-oxidants and antioxidants could lead to a number of female reproductive diseases. This review focuses on the mechanism of OS and a series of female reproductive processes, explaining the role of OS in female reproduction and female reproductive diseases caused by OS, including polycystic ovary syndrome (PCOS), endometriosis, preeclampsia and so on. Many signaling pathways involved in female reproduction, including the Keap1-Nrf2, NF-κB, FOXO and MAPK pathways, which are affected by OS, are described, providing new ideas for the mechanism of reproductive diseases.

Indexed as

Oxidative StressReproductionAnimalsFemaleGenital Diseases, FemaleHumansInfertility, FemalePregnancyReactive Oxygen SpeciesReactive Oxygen SpeciesAntioxidantsFemale fertilityImbalanceOxidative stressReproductive diseasesROSSignaling pathways

Identifiers

PMID30126412
PMCPMC6102891
OpenAlexW2888676896

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.