ArticleDiabetes2018
Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell.
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In one paragraph
Article in Diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 67 citations in OpenAlex.
- The comparative cell physiology of stem cell-derived and primary human β cells.Nature reviews. Endocrinology · 2026Review
- Orai1-mediated CaExperimental & molecular medicine · 2026Article
- Vitamin K as an Endocrine Modulator: Mechanistic Links to Glucose Metabolism and Beyond.Nutrients · 2026Review
- Molecular and Inflammatory Etiologies of β-Cell Dysfunction in Type 1 Diabetes.Physiology (Bethesda, Md.) · 2025Review
- Histidine decarboxylase inhibition attenuates cancer-associated muscle wasting.The Journal of experimental medicine · 2025Article
- Orai channel pharmacological manipulation reduces metabolic flexibility in cardiac fibroblasts.American journal of physiology. Cell physiology · 2025Article
- Reciprocal rescue of Wolfram syndrome by two causative genes.EMBO reports · 2025Article
- The Molecular Biology of Placental Transport of Calcium to the Human Foetus.International journal of molecular sciences · 2025Review
- Sodium butyrate prevents cytokine-induced β-cell dysfunction through restoration of stromal interaction molecule 1 expression and activation of store-operated calcium entry.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Disrupted Endoplasmic Reticulum CaBiology · 2024Review
- The Ailing β-Cell in Diabetes: Insights From a Trip to the ER: The 2023 Outstanding Scientific Achievement Award Lecture.Diabetes · 2024Review
- Molecular mechanism responsible for sex differences in electrical activity of mouse pancreatic β cells.JCI insight · 2024Article
- Advanced Imaging Techniques for the Characterization of Subcellular Organelle Structure in Pancreatic Islet β Cells.Comprehensive Physiology · 2023Article
- SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells.Diabetologia · 2023Article
- Article
- Role of STIM1 in the Regulation of Cardiac Energy Substrate Preference.International journal of molecular sciences · 2023Review
- Vitamin K-dependent carboxylation regulates CaCell reports · 2023Article
- Targeting unfolded protein response reverts ER stress and ER CaJournal of translational medicine · 2023Article
- TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.JCI insight · 2023Article
- Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease.Cold Spring Harbor perspectives in biology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Tatsuyoshi KonoDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN cevansmo@iu.edu konot@iu.edu.
Xin TongDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Solaema TalebDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Robert N BoneDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Hitoshi IidaDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Chih-Chun LeeDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Paul SohnDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN.
Patrick GilonPôle d'endocrinologie, diabète et nutrition, Institut de recherche expérimentale et clinique, Université catholique de Louvain, Brussels, Belgium.ORCID 0000-0002-5885-8347
Michael W RoeDepartment of Medicine, SUNY Upstate Medical University, Syracuse, NY.
Carmella Evans-MolinaDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN cevansmo@iu.edu konot@iu.edu.ORCID 0000-0001-7764-8663
Indiana University School of MedicineRichard L. Roudebush VA Medical Center · USSUNY Upstate Medical University · USUCLouvain · BEVanderbilt University · US
Funding
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4MImmunology and Infectious Diseases Training ProgramT32AI060519 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MARK H KAPLAN · 2004 to 2026
$6.0MMechanisms of Beta Cell Function in Health and DiseaseR01DK093954 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EVANS-MOLINA, CARMELLA · 2011 to 2019
$3.5MBiomarkers Of Beta Cell Stress In Type 1 Diabetes (BetaMarker)UC4DK104166 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EIZIRIK, DECIO LAKS, EVANS-MOLINA, CARMELLA · 2014 to 2014
$2.4MMolecular Physiology of Store-Dependant Calcium Entry in Pancreatic Beta Cells.R01DK092616 · NIDDK · UPSTATE MEDICAL UNIVERSITY · PI ROE, MICHAEL WILLIAM · 2012 to 2015
$1.9MCalcium Signaling in Pancreatic Beta Cell Endoplasmic ReticulumR01DK074966 · NIDDK · UPSTATE MEDICAL UNIVERSITY · PI ROE, MICHAEL WILLIAM · 2006 to 2010
$1.4MRegulation of Calcium Homeostasis in the Pancreatic Beta CellI01BX001733 · VA · RLR VA MEDICAL CENTER · PI Carmella Evans-Molina · 2013 to 2026
–BLRD VA I01 BX001733NIAID NIH HHS T32 AI060519NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK074966NIDDK NIH HHS R01 DK092616NIDDK NIH HHS R01 DK093954NIDDK NIH HHS UC4 DK104166
Abstract
Store-operated Ca
Indexed as
AnimalsCalciumCell LineDiabetes Mellitus, ExperimentalEndoplasmic Reticulum StressGlucoseHumansInsulinInsulin-Secreting CellsMiceRatsStromal Interaction Molecule 1CalciumGlucoseInsulinStromal Interaction Molecule 1
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.