Evidence map›Paper›PMID 30132344›Full record

ArticleAmerican journal of physiology. Renal physiology2018

Downregulation of microRNA-429 contributes to angiotensin II-induced profibrotic effect in rat kidney.

Zhengchao Wang, Qing Zhu, Weili Wang, Junping Hu, Pin-Lan Li, Fan Yi, Ningjun Li

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Zhengchao WangDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University , Richmond, Virginia.
Qing ZhuDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University , Richmond, Virginia.
Weili WangDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University , Richmond, Virginia.
Junping HuDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University , Richmond, Virginia.
Pin-Lan LiDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University , Richmond, Virginia.
Fan YiDepartment of Pharmacology, Shandong University School of Medicine , Jinan , People's Republic of China.
Ningjun LiDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University , Richmond, Virginia.
Virginia Commonwealth University Medical Center · USFujian Normal University · CNGuangdong Pharmaceutical University · CNShandong University · CN

Funding

Renal Medullary HIF Prolyl Hydroxylases and Salt Sensitivity of Blood PressureR01HL089563 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, NINGJUN · 2007 to 2016
$3.4M
Renal Medullary Stem Cell Niche in Salt Sensitive HypertensionR01HL106042 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, NINGJUN · 2011 to 2014
$1.5M
Molecular mechanism of hypertension-induced renal injury: the role of HIF-1alphaR01DK107991 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, NINGJUN · 2017 to 2019
$698k
NHLBI NIH HHS R01 HL089563NHLBI NIH HHS R01 HL106042NIDDK NIH HHS R01 DK107991
6 · The paper itself

Abstract

MicroRNA (miR) 429 has been shown to inhibit epithelial-to-mesenchymal transition (EMT) in cancer cells. However, the role of miR429 in EMT in non-cancer cells has not been defined, especially in the kidneys. The present study determined whether miR429 participated in angiotensin (ANG) II-induced EMT and fibrogenesis in renal cells. In NRK-52E cells, a rat proximal tubular cell line, incubation of ANG II (10

Indexed as

ActinsAlbuminuriaAngiotensin IIAnimalsCadherinsCalcium-Binding ProteinsCell LineCell TransdifferentiationCollagenDown-RegulationEpithelial-Mesenchymal TransitionFibrosisKidney Tubules, ProximalMaleMicroRNAsPodocytesActa2 protein, ratActinsAngiotensin IICadherinsCalcium-Binding ProteinsCDH1 protein, ratCollagenFSP1 protein, ratMicroRNAsMIRN429 microRNA, ratalbuminuriaepithelial-to-mesenchymal transitionproximal tubular cell

Identifiers

PMID30132344
PMCPMC6336989
OpenAlexW2888603757

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.