Evidence map›Paper›PMID 30135309›Full record

Trial reportJCI insight2018

Chronic kidney disease attenuates the plasma metabolome response to insulin.

Baback Roshanravan, Leila R Zelnick, Daniel Djucovic, Haiwei Gu, Jessica A Alvarez, Thomas R Ziegler, Jorge L Gamboa, Kristina Utzschneider, Bryan Kestenbaum, Jonathan Himmelfarb and 3 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JCI insight, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Chronic Kidney Disease is Associated With Attenuated Plasma Metabolome Response to Oral Glucose Tolerance Testing.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Baback RoshanravanDivision of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, USA.
Leila R ZelnickDivision of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, USA.
Daniel DjucovicAnesthesiology and Pain Medicine, University of Washington, Seattle, Washington, USA.
Haiwei GuAnesthesiology and Pain Medicine, University of Washington, Seattle, Washington, USA.
Jessica A AlvarezDivision of Endocrinology, Metabolism and Lipids, Emory University, Atlanta, Georgia, USA.
Thomas R ZieglerDivision of Endocrinology, Metabolism and Lipids, Emory University, Atlanta, Georgia, USA.
Jorge L GamboaDepartment of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.
Kristina UtzschneiderPuget Sound Health Care System, Seattle, Washington, USA.
Bryan KestenbaumDivision of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, USA.
Jonathan HimmelfarbDivision of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, USA.
Steven E KahnPuget Sound Health Care System, Seattle, Washington, USA.
Daniel RafteryAnesthesiology and Pain Medicine, University of Washington, Seattle, Washington, USA.
Ian H de BoerDivision of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, USA.
University of Washington · USEmory University · USVanderbilt University · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · 1986 to 2025
$12.6M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · UNIVERSITY OF WASHINGTON · 1986 to 2025
$7.0M
NIDDK NIH HHS K01 DK102851NIDDK NIH HHS K23 DK099442NIDDK NIH HHS K23 DK100533NIDDK NIH HHS K24 DK096574NIDDK NIH HHS L30 DK099909NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK087726NIDDK NIH HHS R01 DK101509NIDDK NIH HHS R03 DK114502
6 · The paper itself

Abstract

Chronic kidney disease (CKD) leads to decreased sensitivity to the metabolic effects of insulin, contributing to protein energy wasting and muscle atrophy. Targeted metabolomics profiling during hyperinsulinemic-euglycemic insulin clamp testing may help identify aberrant metabolic pathways contributing to insulin resistance in CKD. Using targeted metabolomics profiling, we examined the plasma metabolome in 95 adults without diabetes in the fasted state (58 with CKD, 37 with normal glomerular filtration rate [GFR]) who underwent hyperinsulinemic-euglycemic clamp. We assessed heterogeneity in fasting metabolites and the response to insulin to identify potential metabolic pathways linking CKD with insulin resistance. Baseline differences and effect modification by CKD status on changes with insulin clamp testing were adjusted for confounders. Mean GFR among participants with CKD was 37.3 compared with 89.3 ml/min per 1.73 m2 among controls. Fasted-state differences between CKD and controls included abnormalities in tryptophan metabolism, ubiquinone biosynthesis, and the TCA cycle. Insulin infusion markedly decreased metabolite levels, predominantly amino acids and their metabolites. CKD was associated with attenuated insulin-induced changes in nicotinamide, arachidonic acid, and glutamine/glutamate metabolic pathways. Metabolomics profiling suggests disruption in amino acid metabolism and mitochondrial function as putative manifestations or mechanisms of the impaired anabolic effects of insulin in CKD.

Indexed as

AgedAmino AcidsBlood GlucoseCross-Sectional StudiesFemaleGlomerular Filtration RateGlucose Clamp TechniqueHealthy VolunteersHumansInsulinInsulin ResistanceMaleMetabolomeMetabolomicsMiddle AgedMitochondriaAmino AcidsBlood GlucoseInsulinAmino acid metabolismInsulinMetabolismMitochondriaNephrology

Identifiers

PMID30135309
PMCPMC6141172
OpenAlexW2888425808

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.