Evidence map›Paper›PMID 30136149›Full record

ArticleJournal of endocrinological investigation2019

Proinflammatory/profibrotic effects of aldosterone in Gitelman's syndrome, a human model opposite to hypertension.

V Ravarotto, F Simioni, C Sabbadin, E Pagnin, G Maiolino, D Armanini, L A Calò

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

V RavarottoDepartment of Medicine-Nephrology, University of Padova, Via Giustiniani, 2, 35128, Padua, Italy.
F SimioniDepartment of Medicine-Nephrology, University of Padova, Via Giustiniani, 2, 35128, Padua, Italy.
C SabbadinDepartment of Medicine-Endocrinology, University of Padova, Padua, Italy.
E PagninDepartment of Medicine-Nephrology, University of Padova, Via Giustiniani, 2, 35128, Padua, Italy.
G MaiolinoDepartment of Medicine-Hypertension, University of Padova, Padua, Italy.
D ArmaniniDepartment of Medicine-Endocrinology, University of Padova, Padua, Italy.
L A CalòDepartment of Medicine-Nephrology, University of Padova, Via Giustiniani, 2, 35128, Padua, Italy. renzcalo@unipd.it.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAldosterone proinflammatory/profibrotic effects are mediated by the induction of mononuclear leucocytes (MNL) to express oxidative stress (OxSt)-related proteins, such as p22

methodsp22

resultsAt basal condition, p22

conclusionsGS patients seem to be protected by the OxSt status induced by aldosterone and revealed in HS. This human model could provide additional clues to highlight the proinflammatory/cardiovascular remodeling effects of aldosterone.

Indexed as

AdultAgedAldosteroneBiomarkersCase-Control StudiesFemaleFibrosisFollow-Up StudiesGitelman SyndromeHumansHypertensionInflammationInflammation MediatorsLeukocytes, MononuclearMaleMiddle AgedAldosteroneBiomarkersCYBA protein, humanInflammation MediatorsMyosin-Light-Chain PhosphataseNADPH OxidasesPPP1R12A protein, humanAldosteroneAngiotensin IIGitelman’s syndromeMononuclear leucocytesOxidative stressRho kinase

Identifiers

PMID30136149
OpenAlexW2888647319

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.