Trial reportThe journal of allergy and clinical immunology. In practice2019
Dietary and Plasma Polyunsaturated Fatty Acids Are Inversely Associated with Asthma and Atopy in Early Childhood.
Trial report in The journal of allergy and clinical immunology. In practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Effects of Maternal Vitamin D Supplementation on Childhood Health.Endocrine reviews · 2026Pooled it
- Precision Medicine in Plant Food Allergy: a Systematic Review of Biomarkers Under a Clinical Approach.Clinical reviews in allergy & immunology · 2026Pooled it
- Effects of Maternal Vitamin D Supplementation on Childhood Health.Endocrine reviews · 2025Pooled it
- Daily egg intake may reduce sensitisation to common allergenic foods among six- to nine-month-old south African infants: A randomized controlled trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Trial
- Integrative analysis of the intestinal metabolome of childhood asthma.The Journal of allergy and clinical immunology · 2019Trial
- Association between factor analysis-derived dietary patterns at 24 months of age and allergic diseases in toddlers.Asia Pacific journal of clinical nutrition · 2026Article
- Fecal metabolome alterations in infants at risk of developing allergies during the first year of life.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Association between polyunsaturated fatty acid intake and allergic rhinitis in children and adolescents: a cross-sectional study of the 2007-2016 NHANES data.Translational pediatrics · 2025Article
- Association between dietary fatty acid intake and preserved ratio impaired spirometry in U.S. adults: a population-based cross-sectional study.Frontiers in nutrition · 2025Article
- Association between omega-6 fatty acid intake and asthma in US children and adolescents.BMC pediatrics · 2024Article
- Plasma metabolomics identifies differing endotypes of recurrent wheezing in preschool children differentiated by symptoms and social disadvantage.Scientific reports · 2024Article
- Metabolomic profiles during early childhood and risk of food allergies and asthma in multiethnic children from a prospective birth cohort.The Journal of allergy and clinical immunology · 2024Article
- Age-specific Metabolomic profiles in children with food allergy.Clinical immunology (Orlando, Fla.) · 2024Article
- The potential role of n-3 fatty acids and their lipid mediators on asthmatic airway inflammation.Frontiers in immunology · 2024Review
- The re-emerging role of linoleic acid in paediatric asthma.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics.International journal of molecular sciences · 2023Review
- The association of polyunsaturated fatty acids and asthma: a cross-sectional study.Journal of health, population, and nutrition · 2023Article
- Omega-3 Fatty Acids Interact withNutrients · 2023Article
- The maternal prenatal and offspring early-life gut microbiome of childhood asthma phenotypes.Allergy · 2023Article
- Screening of Lipid Metabolism-Related Genes as Diagnostic Indicators in Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundPolyunsaturated fatty acids (PUFAs) influence immune function and risk of allergic disease. Prior evidence of the effect of PUFA intake on childhood asthma and allergy is inconclusive.
objectivesTo investigate associations of PUFA plasma levels and dietary intake with asthma and allergy at age 3 years in this ancillary study of the Vitamin D Antenatal Asthma Reduction Trial.
methodsPlasma PUFA levels were reported as relative abundances from mass spectrometry profiling, and dietary PUFA intake was derived from food frequency questionnaire responses. Associations between PUFA and outcomes, including asthma and/or recurrent wheeze, allergic sensitization, and total IgE at age 3 years, were evaluated in adjusted regression models. Additional regression models analyzed the combined effects of antenatal vitamin D and early childhood PUFA on outcomes.
resultsTotal, omega-3, and omega-6 plasma PUFA relative abundances were significantly (P < .05) inversely associated with both asthma and/or recurrent wheeze and allergic sensitization. Likewise, dietary PUFA intake was inversely associated with asthma and/or recurrent wheeze (P < .05 for omega-6 PUFA only). For both dietary and plasma measures of total, omega-3, and omega-6 PUFAs, inverse associations with outcomes were strongest among subjects with both high umbilical cord blood 25-hydroxyvitamin D and high PUFA at age 3 years.
conclusionsPUFA dietary intake and plasma levels are inversely associated with asthma and/or recurrent wheeze and atopy at age 3 years. Antenatal vitamin D could modulate the effect of early childhood PUFA on risk of asthma and allergy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.