Evidence map›Paper›PMID 30145729›Full record

ReviewCurrent diabetes reports2018

The Potential Role of Fatty Acids in Treating Diabetic Neuropathy.

Mark A Yorek

Open access · greenAbstract readReview
In one paragraph

Review in Current diabetes reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  3. Article
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  7. Article
  8. Review
  9. Molecular Pharmacology of Inflammation Resolution in Atherosclerosis.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Nutritional Values of Teff (Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Mark A YorekDepartment of Veterans Affairs Iowa City Health Care System, Room 127, Building 41, Iowa City, IA, 52246, USA. mark-yorek@uiowa.edu.
Iowa City VA Health Care System · US

Funding

Effect of exogenous fatty acids on diabetes neural/neurovascular complicationsR01DK107399 · NIDDK · UNIVERSITY OF IOWA · PI YOREK, MARK A. · 2016 to 2019
$1.1M
Diabetic Neuropathy: Function-Structure of Corneal Nerves to Assess Injury-RepairI01RX000889 · VA · IOWA CITY VA MEDICAL CENTER · PI KARDON, RANDY H., YOREK, MARK A. · 2015 to 2022
–
NIDDK NIH HHS R01 DK107399RRD VA I01 RX000889
6 · The paper itself

Abstract

purpose of reviewThis review will summarize recent findings of the effect of supplemental fatty acids, with an emphasis on omega-3 polyunsaturated fatty acids, as a treatment for diabetic peripheral neuropathy. RECENT

findingsPre-clinical studies have provided evidence that treating diabetic rodents with δ linolenic acid (omega-6 18:3) and to a greater extent with eicosapentaenoic and docosahexaenoic acids (omega-3 20:5 and 22:6, respectively) improve and even reverse vascular and neural deficits. Additional studies have shown resolvins, metabolites of eicosapentaenoic and docosahexaenoic acids, can induce neurite outgrowth in neuron cultures and that treating type 1 or type 2 diabetic mice with resolvin D1 or E1 provides benefit for peripheral neuropathy similar to fish oil. Omega-3 polyunsaturated fatty acids derived from fish oil and their derivatives have anti-inflammatory properties and could provide benefit for diabetic peripheral neuropathy. However, clinical trials are needed to determine whether this statement is true.

Indexed as

AnimalsDiabetic NeuropathiesDietFatty AcidsFish OilsHumansFatty AcidsFish OilsDiabetic peripheral neuropathyInflammatory stressOmega-3 polyunsaturated fatty acidsOmega-6 polyunsaturated fatty acidsOxidative stressResolvin

Identifiers

PMID30145729
PMCPMC6816026
OpenAlexW2888153087

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.