Other glucose-lowering × hypoglycaemia

ArticlePloS one2018

Comparison of antidiabetic drugs added to sulfonylurea monotherapy in patients with type 2 diabetes mellitus: A network meta-analysis.

Dan Qian et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 10,032 people · 2018

Randomised comparison

Lowered glycemic control

−0.30percentage points−0.55 to −0.05

As reported

difference −0.30 %, 95% CI −0.55 to −0.05

Randomised comparison

Lowered glycemic control

−2.77mmol/l−4.14 to −1.40

As reported

difference −2.77 mmol/l, 95% CI −4.14 to −1.40

Randomised comparison

Lowered body weight & composition

−2.91kg−4.15 to −1.68

As reported

difference −2.91 kg, 95% CI −4.15 to −1.68

Range includes no effect

No clear effect on hypoglycaemia

1.4×0.8× to 2.3×

Bigger than 6 in 10 on the map

As reported

OR 1.35, 95% CI 0.81–2.25

+2 more in the walkthrough ↓

Six numbers in the abstract

the abstract, start to end

inhibitor (SGLT-2i) [OR, 1.35 (95% CI: 0.81 to 2.25)] or alpha-glucosidase inhibitor (AGI) [OR, 1.16 (95% CI: 0.55 to 2.44)].

differences ranged from a reduction of -0.30% (95% CI: -0.55 to -0.05) for

risk of hypoglycemia, except Met [OR, 0.58 (95% CI: 0.29 to 1.18)] and

agents combined with SU, ranging from -2.77 mmol/l (95% CI: -4.14 to -1.40)

and DPP-4i, with changes ranging from -2.91 kg (95% CI: -4.15 to -1.68) for

← favours treatmentfavours comparator →
could be chance
Hypoglycaemia
OR 1.350.81–2.25
Hypoglycaemia
OR 1.160.55–2.44
Glycemic control
−0.30−0.55 to −0.05
Hypoglycaemia
OR 0.580.29–1.18
Glycemic control
−2.77−4.14 to −1.40
Body weight & composition
−2.91−4.15 to −1.68
MetforminSulfonylureas & glinidesOther glucose-loweringGlycemic controlBody weight & compositionHypoglycaemia

Other glucose-lowering × hypoglycaemiaharms?mixed

unlikelylikely
0.00not counted
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Full record →Abstract, authors, funding and every citing paper · PMID 30148851